ReviewClinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association2013
Diverticular disease: reconsidering conventional wisdom.
Review in Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 3 syntheses or guidelines pooled it, 97 citations in OpenAlex.
- Systematic review and meta-analysis on key controversies in the management of diverticular disease: a multi-society collaboration.Surgical endoscopy · 2026Pooled it
- Mesalamine (5-ASA) for the prevention of recurrent diverticulitis.The Cochrane database of systematic reviews · 2017Pooled it
- Routine colonoscopy is not required in uncomplicated diverticulitis: a systematic review.Surgical endoscopy · 2014Pooled it
- Management of symptomatic uncomplicated diverticular disease (SUDD) of the colon with Clostridium butyricum CBM588 versus rifaximin: a retrospective cross-sectional study.International journal of colorectal disease · 2025Trial
- Insights into Probiotic Prescription among Gastroenterologists and Other Healthcare Professionals: Evidence from an Italian Survey.Journal of clinical medicine · 2024Article
- Diagnostic delay in symptomatic uncomplicated diverticular disease: an Italian tertiary referral centre study.Internal and emergency medicine · 2024Article
- Concomitant diverticulosis among patients undergoing liver transplantation. Does it influence the length of hospitalization after the procedure?Clinical and experimental hepatology · 2023Article
- Diverticular Disease and Rifaximin: An Evidence-Based Review.Antibiotics (Basel, Switzerland) · 2023Review
- Pathophysiology of Diverticular Disease: From Diverticula Formation to Symptom Generation.International journal of molecular sciences · 2022Review
- Update on the management of sigmoid diverticulitis.World journal of gastroenterology · 2021Review
- Long-Term Functional Results of a Modified Caudal-to-Cranial Approach in Laparoscopic Segmental Left Colectomy for Diverticular Disease.Gastroenterology research and practice · 2021Article
- Colonic diverticular disease in autosomal dominant polycystic kidney disease: is there really an association? A nationwide analysis.International journal of colorectal disease · 2021Article
- Diverticular Disease: A Review on Pathophysiology and Recent Evidence.The Ulster medical journal · 2020Review
- Colonic diverticular disease.Nature reviews. Disease primers · 2020Review
- Demographic and clinical features distinguish subgroups of diverticular disease patients: Results from an Italian nationwide registry.United European gastroenterology journal · 2018Article
- Quality of life after laparoscopic sigmoid resection for uncomplicated diverticular disease.International journal of colorectal disease · 2018Article
- Relationship between diverticulosis and nonalcoholic fatty liver disease in elderly patients.The Journal of international medical research · 2018Article
- Diverticular Disease: An Update on Pathogenesis and Management.Gut and liver · 2018Review
- RNA-seq implicates deregulation of the immune system in the pathogenesis of diverticulitis.American journal of physiology. Gastrointestinal and liver physiology · 2017Article
- Logical hypothesis: Low FODMAP diet to prevent diverticulitis.World journal of gastrointestinal pharmacology and therapeutics · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Colonic diverticula are common in developed countries and complications of colonic diverticulosis are responsible for a significant burden of disease. Several recent publications have called into question long-held beliefs about diverticular disease. Contrary to conventional wisdom, studies have not shown that a high-fiber diet protects against asymptomatic diverticulosis. The risk of developing diverticulitis among individuals with diverticulosis is lower than the 10% to 25% proportion that commonly is quoted, and may be as low as 1% over 11 years. Nuts and seeds do not increase the risk of diverticulitis or diverticular bleeding. It is unclear whether diverticulosis, absent diverticulitis, or overt colitis is responsible for chronic gastrointestinal symptoms or worse quality of life. The role of antibiotics in acute diverticulitis has been challenged by a large randomized trial that showed no benefit in selected patients. The decision to perform elective surgery should be made on a case-by-case basis and not routinely after a second episode of diverticulitis, when there has been a complication, or in young people. A colonoscopy should be performed to exclude colon cancer after an attack of acute diverticulitis but may not alter outcomes among individuals who have had a colonoscopy before the attack. Given these surprising findings, it is time to reconsider conventional wisdom about diverticular disease.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.