ArticleAIDS (London, England)2013
Comparisons of creatinine and cystatin C for detection of kidney disease and prediction of all-cause mortality in HIV-infected women.
Article in AIDS (London, England), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- The predictive accuracy of machine learning for the risk of death in HIV patients: a systematic review and meta-analysis.BMC infectious diseases · 2024Pooled it
- Reductions in Plasma Cystatin C After Initiation of Antiretroviral Therapy Are Associated With Reductions in Inflammation: ACTG A5224s.Journal of acquired immune deficiency syndromes (1999) · 2015Trial
- Construction and validation of a prognostic nomogram for predicting the survival of HIV/AIDS adults who received antiretroviral therapy: a cohort between 2003 and 2019 in Nanjing.BMC public health · 2022Article
- Soluble Insulin Receptor Levels in Plasma, Exosomes, and Urine and Its Association With HIV-Associated Neurocognitive Disorders.Frontiers in neurology · 2022Article
- Kidney tubule health scores and their associations with incident CKD in women living with HIV.HIV medicine · 2021Article
- Brief Report: Cystatin C-Based Estimation of Glomerular Filtration Rate and Association With Atherosclerosis Imaging Markers in People Living With HIV.Journal of acquired immune deficiency syndromes (1999) · 2020Article
- Association of Statin Use With Kidney Damage and Function Among HIV-Infected Men.Journal of acquired immune deficiency syndromes (1999) · 2019Article
- Associations of Urine Biomarkers with Kidney Function Decline in HIV-Infected and Uninfected Men.American journal of nephrology · 2019Article
- Systolic blood pressure, routine kidney variables and renal ultrasonographic findings in cats naturally infected with feline immunodeficiency virus.Journal of feline medicine and surgery · 2017Article
- Racial Disparities in Creatinine-based Kidney Function Estimates Among HIV-infected Adults.Ethnicity & disease · 2016Article
- Correlation of cystatin C and creatinine based estimates of renal function in children with hydronephrosis.Journal of renal injury prevention · 2016Article
- Cystatin C Falsely Underestimated GFR in a Critically Ill Patient with a New Diagnosis of AIDS.Case reports in nephrology · 2016Article
- Markers of renal disease and function are associated with systemic inflammation in HIV infection.HIV medicine · 2015Article
- Article
- Applicability of estimating glomerular filtration rate equations in pediatric patients: comparison with a measured glomerular filtration rate by iohexol clearance.Translational research : the journal of laboratory and clinical medicine · 2015Article
- Association of urine α1-microglobulin with kidney function decline and mortality in HIV-infected women.Clinical journal of the American Society of Nephrology : CJASN · 2015Article
- Serum albumin and kidney function decline in HIV-infected women.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2014Observational
- Urinary biomarkers of kidney injury are associated with all-cause mortality in the Women's Interagency HIV Study (WIHS).HIV medicine · 2014Article
- Cystatin C-based renal function changes after antiretroviral initiation: a substudy of a randomized trial.Open forum infectious diseases · 2014Article
- Does HIV infection promote early kidney injury in women?Antiviral therapy · 2014Article
Corrections and comments
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Authors and funding
14 authors at 10 institutions in 1 country.
Funding
Abstract
backgroundCystatin C could improve chronic kidney disease (CKD) classification in HIV-infected women relative to serum creatinine.
designRetrospective cohort analysis.
methodsCystatin C and creatinine were measured from specimens taken and stored during the 1999-2000 examination among 908 HIV-infected participants in the Women's Interagency HIV study (WIHS). Mean follow-up was 10.2 years. Predictors of differential glomerular filtration rate (GFR) estimates were evaluated with multivariable linear regression. The associations of baseline categories (<60, 60-90, and >90 ml/min per 1.73 m) of creatinine estimated GFR (eGFRcr), cystatin C eGFR (eGFRcys), and combined creatinine-cystatin C eGFR (eGFRcr-cys) with all-cause mortality were evaluated using multivariable Cox regression. The net reclassification index (NRI) was calculated to evaluate the effect of cystatin C on reclassification of CKD staging.
resultsCKD risk factors were associated with lower eGFRcys and eGFRcr-cys values compared with eGFRcr. Relative to eGFR more than 90, the eGFR less than 60 category by eGFRcys (Adjusted hazard ratio: 2.56; 95% confidence interval: 1.63-4.02), eGFRcr-cys (3.11; 1.94-5.00), and eGFRcr (2.34; 1.44-3.79) was associated with increased mortality risk. However, the eGFR 60-90 category was associated with increased mortality risk for eGFRcys (1.80; 1.28-2.53) and eGFRcr-cys (1.91; 1.38-2.66) but not eGFRcr (1.20; 0.85-1.67). The overall NRI for mortality was 26% when reclassifying from eGFRcr to eGFRcys (P < 0.001) and was 20% when reclassifying from eGFRcr to eGFRcr-cys (P < 0.001).
conclusionThe addition of cystatin C may improve mortality risk prediction by stages of kidney function relative to creatinine. CKD risk factors are associated with an overestimate of GFR by serum creatinine relative to cystatin C.
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