Evidence map›Paper›PMID 23668474›Full record

ReviewThe British journal of dermatology2013

Pathogenesis of infantile haemangioma.

S Greenberger, J Bischoff

Open access · bronzeAbstract readReview
In one paragraph

Review in The British journal of dermatology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers.

0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed
11.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

61 citing papers in PubMed, 180 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Article
  6. KRIT1 in vascular biology and beyond.Bioscience reports · 2024
    Review
  7. Review
  8. Article
  9. Infantile hemangioma: the common and enigmatic vascular tumor.The Journal of clinical investigation · 2024
    Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Novel roles of METTL1/WDR4 in tumor via mMolecular therapy oncolytics · 2022
    Review
  20. Article

1 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 2 countries.

S GreenbergerThe Department of Dermatology, Sheba Medical Center, Ramat-Gan 52621, Israel. Shoshana.Greenberger@sheba.health.gov.il
J Bischoff
Boston Children's Hospital · USSheba Medical Center · IL

Funding

Pathogenic mechanisms of venous anomaliesP01AR048564 · NIAMS · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI OLSEN, BJORN REINO · 2003 to 2013
$13.4M
Blood vessel assembly from multipotent hemangioma-derived stem cellsR01HL096384 · NHLBI · BOSTON CHILDREN'S HOSPITAL · PI Joyce E. Bischoff · 2009 to 2026
$7.7M
NHLBI NIH HHS R01 HL 096384NHLBI NIH HHS R01 HL096384NIAMS NIH HHS P01 AR048564NIAMS NIH HHS P01 AR48564
6 · The paper itself

Abstract

Haemangioma is a vascular tumour of infancy that is well known for its rapid growth during the first weeks to months of a child's life, followed by a spontaneous but slow involution. During the proliferative phase, the vessels are disorganized and composed of immature endothelial cells. When the tumour involutes, the vessels mature and enlarge but are reduced in number. Fat, fibroblasts and connective tissue replace the vascular tissue, with few, large, feeding and draining vessels evident. Both angiogenesis and vasculogenesis have been proposed as mechanisms contributing to the neovascularization in haemangioma tumours. In recent years, several of the 'building blocks', the cells comprising the haemangioma, have been isolated. Among them are haemangioma progenitor/stem cells, endothelial cells and pericytes. This review focuses on these cell types, and the molecular pathways within these cells that have been implicated in driving the pathogenesis of infantile haemangioma.

Indexed as

Adrenal Cortex HormonesAdrenergic beta-AntagonistsAngiopoietinsEmbryonic Stem CellsEndothelium, VascularHemangiomaHumansInfantMast CellsPropranololReceptors, NotchReceptors, Vascular Endothelial Growth FactorReceptor, TIE-2Signal TransductionSkin NeoplasmsTOR Serine-Threonine KinasesAdrenal Cortex HormonesAdrenergic beta-AntagonistsAngiopoietinsMTOR protein, humanPropranololReceptors, NotchReceptors, Vascular Endothelial Growth FactorReceptor, TIE-2TOR Serine-Threonine KinasesVascular Endothelial Growth Factor A

Identifiers

PMID23668474
PMCPMC3707963
OpenAlexW2041335901

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.