ArticleAmerican journal of respiratory and critical care medicine2013
Effects of allergic phenotype on respiratory symptoms and exacerbations in patients with chronic obstructive pulmonary disease.
Article in American journal of respiratory and critical care medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
48 citing papers in PubMed, 2 syntheses or guidelines pooled it, 107 citations in OpenAlex.
- Clinical Phenotypes of Atopy and Asthma in COPD: A Meta-analysis of SPIROMICS and COPDGene.Chest · 2020Pooled it
- The global impact of Aspergillus infection on COPD.BMC pulmonary medicine · 2020Pooled it
- Fungal Sensitization and the Manifestation of Asthmatic Features in Chronic Obstructive Pulmonary Disease.Internal medicine (Tokyo, Japan) · 2026Article
- Association of Short-Term Pollen Exposure With Lung Function in COPD Patients.Chronic obstructive pulmonary diseases (Miami, Fla.) · 2026Article
- Type 2 Inflammation in Asthma and COPD: Biomarkers, Clinical Applications, and Targeted Therapies.Journal of inflammation research · 2026Review
- Efficacy and Safety ofFood science & nutrition · 2026Article
- Tertiary Lymphoid Structures Across Organs: Context, Composition, and Clinical Levers.Immunological reviews · 2025Review
- No evidence for additional systemic eosinophil mobilization during exacerbations in patients with COPD and chronic bronchitis but no allergy.Frontiers in medicine · 2025Article
- Staphylococcus aureus enterotoxin sensitization is associated with declined capsaicin cough sensitivity in chronic obstructive pulmonary disease.Scientific reports · 2024Article
- Clinical Characteristics of T2-Low and T2-High Asthma-Chronic Obstructive Pulmonary Disease Overlap: Findings From COREA Cohort.Allergy, asthma & immunology research · 2024Article
- Type 2 Biomarkers and Their Clinical Implications in Bronchiectasis: A Prospective Cohort Study.Lung · 2024Article
- Comorbid allergy and rhinitis and patient-related outcomes in asthma and COPD: a cross-sectional study.European clinical respiratory journal · 2024Article
- Staphylococcus aureus enterotoxin A- and B-specific IgE in chronic obstructive pulmonary disease.Respiratory research · 2023Article
- Aspergillus infection in chronic obstructive pulmonary diseases.The clinical respiratory journal · 2023Review
- Nasal biomarkers of immune function differ based on smoking and respiratory disease status.Physiological reports · 2023Article
- Factors Associated with Chronic Obstructive Pulmonary Disease: A Hospital-Based Case-Control Study.International journal of chronic obstructive pulmonary disease · 2023Article
- Pollen Exposure and Cardiopulmonary Health Impacts in Adelaide, South Australia.International journal of environmental research and public health · 2022Article
- Predictors of chronic obstructive pulmonary disease in women who have never smoked: a cohort study.ERJ open research · 2022Article
- Home Dust Allergen Exposure Is Associated with Outcomes among Sensitized Individuals with Chronic Obstructive Pulmonary Disease.American journal of respiratory and critical care medicine · 2022Observational
- Omalizumab in middle-aged or older patients with severe allergic asthma-COPD overlap.Postepy dermatologii i alergologii · 2022Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
rationaleChronic obstructive pulmonary disease (COPD) guidelines make no recommendations for allergy diagnosis or treatment.
objectivesTo determine whether an allergic phenotype contributes to respiratory symptoms and exacerbations in patients with COPD.
methodsTwo separate cohorts were analyzed: National Health and Nutrition Survey III (NHANES III) and the COPD and domestic endotoxin (CODE) cohort. Subjects from NHANES III with COPD (n = 1,381) defined as age > 40 years, history of smoking, FEV1/FVC < 0.70, and no diagnosis of asthma were identified. The presence of an allergic phenotype (n = 296) was defined as self-reported doctor diagnosed hay fever or allergic upper respiratory symptoms. In CODE, former smokers with COPD (n = 77) were evaluated for allergic sensitization defined as a detectable specific IgE to perennial allergens. Bivariate and multivariate models were used to determine whether an allergic phenotype was associated with respiratory symptoms and exacerbations. MEASUREMENTS AND MAIN
resultsIn NHANES III, multivariate analysis revealed that individuals with allergic phenotype were more likely to wheeze (odds ratio [OR], 2.1; P < 0.01), to have chronic cough (OR, 1.9; P = 0.01) and chronic phlegm (OR, 1.5; P < 0.05), and to have increased risk of COPD exacerbation requiring an acute doctor visit (OR, 1.7; P = 0.04). In the CODE cohort, multivariate analysis revealed that sensitized subjects reported more wheeze (OR, 5.91; P < 0.01), more nighttime awakening due to cough (OR, 4.20; P = 0.03), increased risk of COPD exacerbations requiring treatment with antibiotics (OR, 3.79; P = 0.02), and acute health visits (OR, 11.05; P < 0.01). An increasing number of sensitizations was associated with a higher risk for adverse health outcomes.
conclusionsAmong individuals with COPD, evidence of an allergic phenotype is associated with increased respiratory symptoms and risk of COPD exacerbations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.