Evidence map›Paper›PMID 23668396›Full record

ReviewDiabetes, obesity & metabolism2014

Diabetes and cancer: two diseases with obesity as a common risk factor.

S K Garg, H Maurer, K Reed, R Selagamsetty

Registry-linked trialOpen access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Diabetes, obesity & metabolism, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03575624 (Changing Health Behaviors to Manage Chronic Conditions in Community-dwelling African American Breast Cancer Survivors), which is not on this map. Cited by 135 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
135citing papers in PubMed, 4 pooled it
5.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03575624 nacompletednot on this mapstarted 2017, after this paper: background citation

Changing Health Behaviors to Manage Chronic Conditions in Community-dwelling African American Breast Cancer Survivors

TypeinterventionalSponsorMount Mary UniversityRan2017 to 2017Enrolled17ConditionsBreast Cancer Female, SurvivorshipArmsNutritional and goal-setting education, yoga
3 · Its place in the literature

Who cites it

135 citing papers in PubMed, 4 syntheses or guidelines pooled it, 272 citations in OpenAlex.

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75 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

S K GargBarbara Davis Center for Diabetes, University of Colorado Denver, Aurora, CO, USA; Diabetes Technology and Therapeutics, New Rochelle, NY, USA; Medicine and Pediatrics, University of Colorado Denver, Aurora, CO, USA.
H Maurer
K Reed
R Selagamsetty
University of Colorado Denver · USUniversity of Colorado Health · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

There is a growing body of evidence to support a connection between diabetes (predominantly type 2), obesity and cancer. Multiple meta-analyses of epidemiological data show that people with diabetes are at increased risk of developing many different types of cancers, along with an increased risk of cancer mortality. Several pathophysiological mechanisms for this relationship have been postulated, including insulin resistance and hyperinsulinaemia, enhanced inflammatory processes, dysregulation of sex hormone production and hyperglycaemia. In addition to these potential mechanisms, a number of common risk factors, including obesity, may be behind the association between diabetes and cancer. Indeed, obesity is associated with an increased risk of cancer and diabetes. Abdominal adiposity has been shown to play a role in creating a systemic pro-inflammatory environment, which could result in the development of both diabetes and cancer. Here, we examine the relationship between diabetes, obesity and cancer, and investigate the potential underlying causes of increased cancer risk in individuals with diabetes. Current treatment recommendations for reducing the overall disease burden are also explored and possible areas for future research are considered.

Indexed as

Diabetes Mellitus, Type 2Gonadal Steroid HormonesHumansHyperglycemiaHyperinsulinismInflammationInsulin ResistanceNeoplasmsObesityObesity, AbdominalPrevalenceRisk FactorsGonadal Steroid Hormonesantidiabetic drugdiabetes complicationsdiabetes mellitustype 2 diabetes

Identifiers

PMID23668396
PMCPMC3904746
OpenAlexW2043984491

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.