ArticleWorld journal of gastrointestinal pharmacology and therapeutics2013
Standard triple versus levofloxacin based regimen for eradication of Helicobacter pylori.
Article in World journal of gastrointestinal pharmacology and therapeutics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 11 citations in OpenAlex.
- Comparison of concomitant therapy versus standard triple-drug therapy for eradication of Helicobacter pylori infection: A prospective open-label randomized controlled trial.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2019Trial
- Sequential versus concomitant therapy for eradication of Helicobacter Pylori in patients with perforated duodenal ulcer: A randomized trial.Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology AssociationTrial
- Choosing optimum regimen for treating Helicobacter pylori infection: Regional data may be the quintessential guide.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2023Article
- The natural history of perforated foregut ulcers after repair by omental patching or primary closure.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2018Article
- Comparison of levofloxacin versus clarithromycin efficacy in the eradication of Helicobacter pylori infection.Caspian journal of internal medicine · 2016Article
- Appropriate first-line regimens to combat Helicobacter pylori antibiotic resistance: an Asian perspective.Molecules (Basel, Switzerland) · 2015Review
- The Comparison of Levofloxacin- and Clarithromycin-Based Bismuth Quadruple Therapy Regimens inJournal of research in pharmacy practiceArticle
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo compare the eradication rates for Helicobacter pylori (H. pylori) and ulcer recurrence of standard triple therapy (STT) and levofloxacin based therapy (LBT).
methodsSeventy-four patients with perforated duodenal ulcer treated with simple closure and found to be H. pylori infected on 3 mo follow up were randomized to receive either the STT group comprising of amoxicillin 1 g bid, clarithromycin 500 mg bid and omeprazole 20 mg bid or the LBT group comprising of amoxicillin 1 g bid, levofloxacin 500 mg bid and omeprazole 20 mg bid for 10 d each. The H. pylori eradication rates, side effects, compliance and the recurrence of ulcer were assessed in the two groups at 3 mo follow up.
resultsThirty-four patients in the STT group and 32 patients in the levofloxacin group presented at 3 mo follow up. H. pylori eradication rates were similar with STT and the LBT groups on intention-to-treat (ITT) analysis (69% vs 80%, P = 0.425) and (79% vs 87%, P = 0.513) by per-protocol (PP) analysis respectively. Ulcer recurrence in the STT and LBT groups on ITT analysis was (20% vs 14%, P = 0.551) and (9% vs 6%, P = 1.00) by PP analysis. Compliance and side effects were also comparable between the groups. A complete course of STT costs Indian Rupees (INR) 1060.00, while LBT costs only INR 360.00.
conclusionH. pylori eradication rates and the rate of ulcer recurrence were similar between the STT and LBT. The LBT is a more economical option compared to STT.
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