ArticleJournal of neurogastroenterology and motility2013
Experimental and Automated Analysis Techniques for High-resolution Electrical Mapping of Small Intestine Slow Wave Activity.
Article in Journal of neurogastroenterology and motility, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.
- Systematic review of small intestine pacing parameters for modulation of gut function.Neurogastroenterology and motility · 2023Pooled it
- Methods and Techniques for Closed-Loop Gastrointestinal Pacing.Neurogastroenterology and motility · 2026Article
- Electromechanical coupling across the gastroduodenal junction.Acta physiologica (Oxford, England) · 2025Review
- Electromechanical Response of Mesenteric Ischemia Defined Through Simultaneous High-Resolution Bioelectrical and Video Mapping.Annals of biomedical engineering · 2024Article
- Relationship Between Intestinal Slow-waves, Spike-bursts, and Motility, as Defined Through High-resolution Electrical and Video Mapping.Journal of neurogastroenterology and motility · 2022Article
- Intraoperative serosal extracellular mapping of the human distal colon: a feasibility study.Biomedical engineering online · 2021Article
- Improved Visualization of Gastrointestinal Slow Wave Propagation Using a Novel Wavefront-Orientation Interpolation Technique.IEEE transactions on bio-medical engineering · 2018Article
- High-resolution electrical mapping of porcine gastric slow-wave propagation from the mucosal surface.Neurogastroenterology and motility · 2017Article
- Progress in Mathematical Modeling of Gastrointestinal Slow Wave Abnormalities.Frontiers in physiology · 2017Review
- Iterative Covariance-Based Removal of Time-Synchronous Artifacts: Application to Gastrointestinal Electrical Recordings.IEEE transactions on bio-medical engineering · 2016Article
- Multi-channel wireless mapping of gastrointestinal serosal slow wave propagation.Neurogastroenterology and motility · 2015Article
- The bioelectrical basis and validity of gastrointestinal extracellular slow wave recordings.The Journal of physiology · 2013Article
- Mapping and modeling gastrointestinal bioelectricity: from engineering bench to bedside.Physiology (Bethesda, Md.) · 2013Review
- The virtual intestine: in silico modeling of small intestinal electrophysiology and motility and the applications.Wiley interdisciplinary reviews. Systems biology and medicineReview
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
BACKGROUND/
aimsSmall intestine motility is governed by an electrical slow wave activity, and abnormal slow wave events have been associated with intestinal dysmotility. High-resolution (HR) techniques are necessary to analyze slow wave propagation, but progress has been limited by few available electrode options and laborious manual analysis. This study presents novel methods for in vivo HR mapping of small intestine slow wave activity.
methodsRecordings were obtained from along the porcine small intestine using flexible printed circuit board arrays (256 electrodes; 4 mm spacing). Filtering options were compared, and analysis was automated through adaptations of the falling-edge variable-threshold (FEVT) algorithm and graphical visualization tools.
resultsA Savitzky-Golay filter was chosen with polynomial-order 9 and window size 1.7 seconds, which maintained 94% of slow wave amplitude, 57% of gradient and achieved a noise correction ratio of 0.083. Optimized FEVT parameters achieved 87% sensitivity and 90% positive-predictive value. Automated activation mapping and animation successfully revealed slow wave propagation patterns, and frequency, velocity, and amplitude were calculated and compared at 5 locations along the intestine (16.4 ± 0.3 cpm, 13.4 ± 1.7 mm/sec, and 43 ± 6 µV, respectively, in the proximal jejunum).
conclusionsThe methods developed and validated here will greatly assist small intestine HR mapping, and will enable experimental and translational work to evaluate small intestine motility in health and disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.