ArticlePloS one2013
Genome wide association study of age at menarche in the Japanese population.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 41 citations in OpenAlex.
- Genome-wide association study of age at menarche in the Taiwan Biobank suggests NOL4 as a novel associated gene.Journal of human genetics · 2023Pooled it
- Pooled it
- Sweeteners and puberty: investigating genetic and dietary influences on central precocious puberty.Journal of endocrinological investigation · 2025Article
- Identification of loci associated with women's reproductive traits and exploration of a shared genetic basis with obesity.Human genomics · 2025Article
- Genetic determinants of age at menarche: does the LIN28B gene play a role? A narrative review.Hormones (Athens, Greece) · 2025Review
- Study ofChildren (Basel, Switzerland) · 2024Article
- Earlier Menarche in Greek Girls Born by Caesarean Section: A Case-Control Study.Journal of clinical medicine · 2024Article
- Genome-wide causal mediation analysis identifies genetic loci associated with uterine fibroids mediated by age at menarche.Human reproduction (Oxford, England) · 2022Article
- Associations between age of menarche and genetic variation in women of African descent: genome-wide association study and polygenic score analysis.Journal of epidemiology and community health · 2022Article
- Gene Polymorphisms Associated with Central Precocious Puberty and Hormone Levels in Chinese Girls.International journal of endocrinology · 2022Article
- Menarche among rural adolescent girls in Dervan (Data from the KONKAN region of the state of Maharashtra, India).Journal of family medicine and primary care · 2020Article
- DDT exposure during pregnancy and DNA methylation alterations in female offspring in the Child Health and Development Study.Reproductive toxicology (Elmsford, N.Y.) · 2020Article
- A novel familial 9q31.2q32 microdeletion: Muscle cramping, somnolence, fatigue, sensorineural hearing loss, pubertal delay, and short stature.Clinical case reports · 2019Article
- Genetics of pubertal timing.Current opinion in pediatrics · 2018Review
- Hypothalamic epigenetics driving female puberty.Journal of neuroendocrinology · 2018Review
- Elucidating the genetic architecture of reproductive ageing in the Japanese population.Nature communications · 2018Article
- Age at menarche and age at natural menopause in East Asian women: a genome-wide association study.Age (Dordrecht, Netherlands) · 2016Article
- Association of genetic polymorphisms around the LIN28B gene and idiopathic central precocious puberty risks among Chinese girls.Pediatric research · 2016Article
- Ovarian Physiology and GWAS: Biobanks, Biology, and Beyond.Trends in endocrinology and metabolism: TEM · 2016Review
- Prospecting major genes in dairy buffaloes.BMC genomics · 2015Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Age at menarche (AAM) is a complex trait involving both genetic and environmental factors. To identify the genetic factors associated with AAM, we conducted a large-scale meta-analysis of genome-wide association studies using more than 15,000 Japanese female samples. Here, we identified an association between SNP (single nucleotide polymorphism) rs364663 at the LIN28B locus and AAM, with a P-value of 5.49×10(-7) and an effect size of 0.089 (year). We also evaluated 33 SNPs that were previously reported to be associated with AAM in women of European ancestry. Among them, two SNPs rs4452860 and rs7028916 in TMEM38B indicated significant association with AAM in the same directions as reported in previous studies (P = 0.0013 with an effect size of 0.051) even after Bonferroni correction for the 33 SNPs. In addition, six loci in or near CCDC85A, LOC100421670, CA10, ZNF483, ARNTL, and RXRG exhibited suggestive association with AAM (P<0.05). Our findings elucidated the impact of genetic variations on AAM in the Japanese population.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.