ArticlePloS one2013
Fusion of ZMYND8 and RELA genes in acute erythroid leukemia.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 44 citations in OpenAlex.
- TheFrontiers in oncology · 2026Article
- Acute Erythroid Leukemia Post-Chemo-Radiotherapy and Autologous Stem Cell Transplantation Due to Multiple Myeloma: Tracing the Paths to Leukemic Transformation.International journal of molecular sciences · 2024Article
- Acute Erythroid Leukemia: From Molecular Biology to Clinical Outcomes.International journal of molecular sciences · 2024Review
- Zinc finger myeloid Nervy DEAF-1 type (ZMYND) domain containing proteins exert molecular interactions to implicate in carcinogenesis.Discover oncology · 2022Review
- Molecular Landscapes and Models of Acute Erythroleukemia.HemaSphere · 2021Review
- Erythroleukemia: an Update.Current oncology reports · 2021Review
- Regulation of ZMYND8 to Treat Cancer.Molecules (Basel, Switzerland) · 2021Review
- Protein kinase C binding protein 1 inhibits hypoxia-inducible factor-1 in the heart.Cardiovascular research · 2019Article
- Genomic subtyping and therapeutic targeting of acute erythroleukemia.Nature genetics · 2019Article
- Low expression of ZMYND8 correlates with aggressive features and poor prognosis in nasopharyngeal carcinoma.Cancer management and research · 2019Article
- "Z4" Complex Member Fusions in NUT Carcinoma: Implications for a Novel Oncogenic Mechanism.Molecular cancer research : MCR · 2018Article
- ZMYND8 acetylation mediates HIF-dependent breast cancer progression and metastasis.The Journal of clinical investigation · 2018Article
- C11orf95-RELA fusions and upregulated NF-KB signalling characterise a subset of aggressive supratentorial ependymomas that express L1CAM and nestin.Journal of neuro-oncology · 2018Article
- Erythroleukemia-historical perspectives and recent advances in diagnosis and management.Blood reviews · 2018Review
- Double duty: ZMYND8 in the DNA damage response and cancer.Cell cycle (Georgetown, Tex.) · 2018Article
- Constitutive Activation of NF-κB Pathway in Hematopoietic Stem Cells Causes Loss of Quiescence and Deregulated Transcription Factor Networks.Frontiers in cell and developmental biology · 2018Article
- Histone demethylase KDM5A regulates the ZMYND8-NuRD chromatin remodeler to promote DNA repair.The Journal of cell biology · 2017Article
- Article
- Acetylation Reader Proteins: Linking Acetylation Signaling to Genome Maintenance and Cancer.PLoS genetics · 2016Review
- Long-Lasting WNT-TCF Response Blocking and Epigenetic Modifying Activities of Withanolide F in Human Cancer Cells.PloS one · 2016Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Acute erythroid leukemia was diagnosed in a 4-month-old boy. Cytogenetic analysis of bone marrow (BM) cells showed a t(11;20)(p11;q11) translocation. RNA extracted from the BM was sequenced and analyzed for fusion transcripts using the software FusionMap. A ZMYND8-RELA fusion was ranked first. RT-PCR and direct sequencing verified the presence of an in frame ZMYND8-RELA chimeric transcript. Fluorescence in situ hybridization showed that the ZMYND8-RELA was located on the p12 band of der(11); therefore a cytogenetically invisible pericentric inversion in chromosome 11 must have taken place besides the translocation. The putative ZMYND8-RELA fusion protein contains the Zinc-PHD finger domain, a bromodomain, a PWWP domain, a MYND type of zinc finger of ZMYND8, and the entire RELA protein, indicating that it might act leukemogenically by influencing several cellular processes including the NF-kappa-B pathway.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.