ArticlePloS one2013
Role of corticosterone on sleep homeostasis induced by REM sleep deprivation in rats.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 39 citations in OpenAlex.
- A novel theory of rapid eye movement sleep as an integral component of the seasonal timekeeping apparatus.Frontiers in neuroscience · 2026Article
- Glucocorticoids and Neutrophil Biology: Impact on the Development of Resistance to Glucocorticoid Therapy.Neuroimmunomodulation · 2026Review
- Phasic Dopamine Release in the Nucleus Accumbens Influences REM Sleep Timing.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Effect of glucocorticoid blockade on inflammatory responses to acute sleep fragmentation in male mice.PeerJ · 2024Article
- Curcumin mitigates the sleep-deprivation impacts on rat hypothalamic paraventricular nucleus.IBRO neuroscience reports · 2023Article
- A wireless and battery-less implant for multimodal closed-loop neuromodulation in small animals.Nature biomedical engineering · 2023Article
- Sleep Deprivation-Induced Oxidative Stress in Rat Models: A Scoping Systematic Review.Antioxidants (Basel, Switzerland) · 2023Article
- The stress of losing sleep: Sex-specific neurobiological outcomes.Neurobiology of stress · 2023Article
- Loss of sleep when it is needed most - Consequences of persistent developmental sleep disruption: A scoping review of rodent models.Neurobiology of sleep and circadian rhythms · 2023Article
- Interactions between Sleep and Emotions in Humans and Animal Models.Medicina (Kaunas, Lithuania) · 2022Review
- The Pituitary-Adrenal Response to Paradoxical Sleep Deprivation Is Similar to a Psychological Stressor, Whereas the Hypothalamic Response Is Unique.Frontiers in endocrinology · 2022Article
- Use of Actigraphy for a Rat Behavioural Sleep Study.Clocks & sleep · 2021Article
- Sleep Disturbance during Infection Compromises Tfh Differentiation and Impacts Host Immunity.iScience · 2020Article
- Sleep deprivation and stress: a reciprocal relationship.Interface focus · 2020Review
- Disruption of Rapid Eye Movement Sleep Homeostasis in Adolescent Rats after Neonatal Anesthesia.Anesthesiology · 2019Article
- Relevance of deprivation studies in understanding rapid eye movement sleep.Nature and science of sleep · 2018Review
- Rat Strain and Housing Conditions Alter Oxidative Stress and Hormone Responses to Chronic Intermittent Hypoxia.Frontiers in physiology · 2018Article
- Functions and Mechanisms of Sleep.AIMS neuroscience · 2016Article
- Renin knockout rat: control of adrenal aldosterone and corticosterone synthesis in vitro and adrenal gene expression.American journal of physiology. Regulatory, integrative and comparative physiology · 2015Article
- Extended wakefulness: compromised metabolics in and degeneration of locus ceruleus neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sleep is regulated by humoral and homeostatic processes. If on one hand chronic elevation of stress hormones impair sleep, on the other hand, rapid eye movement (REM) sleep deprivation induces elevation of glucocorticoids and time of REM sleep during the recovery period. In the present study we sought to examine whether manipulations of corticosterone levels during REM sleep deprivation would alter the subsequent sleep rebound. Adult male Wistar rats were fit with electrodes for sleep monitoring and submitted to four days of REM sleep deprivation under repeated corticosterone or metyrapone (an inhibitor of corticosterone synthesis) administration. Sleep parameters were continuously recorded throughout the sleep deprivation period and during 3 days of sleep recovery. Plasma levels of adrenocorticotropic hormone and corticosterone were also evaluated. Metyrapone treatment prevented the elevation of corticosterone plasma levels induced by REM sleep deprivation, whereas corticosterone administration to REM sleep-deprived rats resulted in lower corticosterone levels than in non-sleep deprived rats. Nonetheless, both corticosterone and metyrapone administration led to several alterations on sleep homeostasis, including reductions in the amount of non-REM and REM sleep during the recovery period, although corticosterone increased delta activity (1.0-4.0 Hz) during REM sleep deprivation. Metyrapone treatment of REM sleep-deprived rats reduced the number of REM sleep episodes. In conclusion, reduction of corticosterone levels during REM sleep deprivation resulted in impairment of sleep rebound, suggesting that physiological elevation of corticosterone levels resulting from REM sleep deprivation is necessary for plentiful recovery of sleep after this stressful event.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.