ArticlePloS one2013
The use of amino sugars by Bacillus subtilis: presence of a unique operon for the catabolism of glucosamine.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 43 citations in OpenAlex.
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- Engineering D-glucose utilization in Azospirillum brasilense Sp7 promotes rice root colonization.Applied microbiology and biotechnology · 2022Article
- Lambda-PCR for precise DNA assembly and modification.Biotechnology and bioengineering · 2022Article
- Comparison and interpretation of freshwater bacterial structure and interactions with organic to nutrient imbalances in restored wetlands.Frontiers in microbiology · 2022Article
- Carbohydrate Metabolism in Bacteria: Alternative Specificities in ADP-Glucose Pyrophosphorylases Open Novel Metabolic Scenarios and Biotechnological Tools.Frontiers in microbiology · 2022Article
- The N-Acetylglucosamine Kinase fromInternational journal of molecular sciences · 2021Article
- Metabolism of Poly-β1,4-Journal of bacteriology · 2021Article
- Design of a programmable biosensor-CRISPRi genetic circuits for dynamic and autonomous dual-control of metabolic flux in Bacillus subtilis.Nucleic acids research · 2020Article
- Metabolic engineering of Bacillus subtilis for production of para-aminobenzoic acid - unexpected importance of carbon source is an advantage for space application.Microbial biotechnology · 2019Article
- Cross Talk among Transporters of the Phosphoenolpyruvate-Dependent Phosphotransferase System in Bacillus subtilis.Journal of bacteriology · 2018Article
- A metabolic checkpoint protein GlmR is important for diverting carbon into peptidoglycan biosynthesis in Bacillus subtilis.PLoS genetics · 2018Article
- Significant release and microbial utilization of amino sugars and D-amino acid enantiomers from microbial cell wall decomposition in soils.Soil biology & biochemistry · 2018Article
- Amino Sugars Enhance the Competitiveness of Beneficial Commensals with Streptococcus mutans through Multiple Mechanisms.Applied and environmental microbiology · 2016Article
- Structure of an ABC transporter solute-binding protein specific for the amino sugars glucosamine and galactosamine.Acta crystallographica. Section F, Structural biology communications · 2016Article
- Allosteric Activation of Escherichia coli Glucosamine-6-Phosphate Deaminase (NagB) In Vivo Justified by Intracellular Amino Sugar Metabolite Concentrations.Journal of bacteriology · 2016Article
- N-acetylglucosamine-Mediated Expression ofFrontiers in cellular and infection microbiology · 2016Article
- NagR Differentially Regulates the Expression of the glmS and nagAB Genes Required for Amino Sugar Metabolism by Streptococcus mutans.Journal of bacteriology · 2015Article
- An Essential Poison: Synthesis and Degradation of Cyclic Di-AMP in Bacillus subtilis.Journal of bacteriology · 2015Article
- The Role of α-CTD in the Genome-Wide Transcriptional Regulation of the Bacillus subtilis Cells.PloS one · 2015Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
B. subtilis grows more rapidly using the amino sugar glucosamine as carbon source, than with N-acetylglucosamine. Genes for the transport and metabolism of N-acetylglucosamine (nagP and nagAB) are found in all the sequenced Bacilli (except Anoxybacillus flavithermus). In B. subtilis there is an additional operon (gamAP) encoding second copies of genes for the transport and catabolism of glucosamine. We have developed a method to make multiple deletion mutations in B. subtilis employing an excisable spectinomycin resistance cassette. Using this method we have analysed the contribution of the different genes of the nag and gam operons for their role in utilization of glucosamine and N-acetylglucosamine. Faster growth on glucosamine is due to the presence of the gamAP operon, which is strongly induced by glucosamine. Although the gamA and nagB genes encode isozymes of GlcN6P deaminase, catabolism of N-acetylglucosamine relies mostly upon the gamA gene product. The genes for use of N-acetylglucosamine, nagAB and nagP, are repressed by YvoA (NagR), a GntR family regulator, whose gene is part of the nagAB yvoA(nagR) operon. The gamAP operon is repressed by YbgA, another GntR family repressor, whose gene is expressed divergently from gamAP. The nagAB yvoA synton is found throughout the Bacilli and most firmicutes. On the other hand the ybgA-gamAP synton, which includes the ybgB gene for a small protein of unknown provenance, is only found in B. subtilis (and a few very close relatives). The origin of ybgBA-gamAP grouping is unknown but synteny analysis suggests lateral transfer from an unidentified donor. The presence of gamAP has enabled B. subtilis to efficiently use glucosamine as carbon source.
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