ArticlePloS one2013
A behavioral paradigm to evaluate hippocampal performance in aged rodents for pharmacological and genetic target validation.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed.
- Dynamic changes in the hippocampal memory index and biochemical indices in Sprague Dawley rats exposed to intrauterine kola nut.Metabolic brain disease · 2024Article
- Lasting mesothalamic dopamine imbalance and altered exploratory behavior in rats after a mild neonatal hypoxic event.Frontiers in integrative neuroscience · 2023Article
- Vanadium improves memory and spatial learning and protects the pyramidal cells of the hippocampus in juvenile hydrocephalic mice.Frontiers in neurology · 2023Article
- Exercise Duration Differentially Effects Age-related Neuroinflammation and Hippocampal Neurogenesis.Neuroscience · 2022Article
- Understanding the Link Between Maternal Overnutrition, Cardio-Metabolic Dysfunction and Cognitive Aging.Frontiers in neuroscience · 2021Review
- Mechanisms of critical period in the hippocampus underlie object location learning and memory in infant rats.Learning & memory (Cold Spring Harbor, N.Y.) · 2018Article
- Memory Improvement Effect of Ethanol Garlic (Evidence-based complementary and alternative medicine : eCAM · 2017Article
- Neurokinin-1 receptor inhibition reverses ischaemic brain injury and dementia in bilateral common carotid artery occluded rats: possible mechanisms.Inflammopharmacology · 2016Article
- Insulin-like growth factor 2 rescues aging-related memory loss in rats.Neurobiology of aging · 2016Article
- Early hippocampal volume loss as a marker of eventual memory deficits caused by repeated stress.Scientific reports · 2016Article
- Learning impairments identified early in life are predictive of future impairments associated with aging.Behavioural brain research · 2015Article
- Hippocampal output area CA1 broadcasts a generalized novelty signal during an object-place recognition task.Hippocampus · 2014Article
Corrections and comments
- Erratum issued
Authors and funding
4 authors.
Funding
Abstract
Aged-related cognitive ability is highly variable, ranging from unimpaired to severe impairments. The Morris water maze (a reliable tool for assessing memory) has been used to distinguish aged rodents that are superior learners from those that are learning impaired. This task, however, is not practical for pre- and post-pharmacological treatment, as the memory of the task is long lasting. In contrast, the object location memory task, also a spatial learning paradigm, results in a less robust memory that decays quickly. We demonstrate for the first time how these two paradigms can be used together to assess hippocampal cognitive impairments before and after pharmacological or genetic manipulations in rodents. Rats were first segregated into superior learning and learning impaired groups using the object location memory task, and their performance was correlated with future outcome on this task and on the Morris water maze. This method provides a tool to evaluate the effect of treatments on cognitive impairment associated with aging and neurodegenerative disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.