ArticlePloS one2013
Epigenetic feedback regulation accelerates adaptation and evolution.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed.
- Article
- Methylation of theMolecules (Basel, Switzerland) · 2019Article
- Methylation of p16 ink4a promoter is independent of human papillomavirus DNA physical state: a comparison between cervical pre-neoplastic and neoplastic samples.Memorias do Instituto Oswaldo Cruz · 2018Article
- Exploratory adaptation in large random networks.Nature communications · 2017Article
- Chromosomal distribution of H3K4me2, H3K9me2 and 5-methylcytosine: variations associated with polyploidy and hybridization in Brachiaria (Poaceae).Plant cell reports · 2016Article
- Pluripotency, Differentiation, and Reprogramming: A Gene Expression Dynamics Model with Epigenetic Feedback Regulation.PLoS computational biology · 2015Article
- Revisiting demographic processes in cattle with genome-wide population genetic analysis.Frontiers in genetics · 2015Article
- Transcriptome-wide variability in single embryonic development cells.Scientific reports · 2014Article
- Heterogeneous structure of stem cells dynamics: statistical models and quantitative predictions.Scientific reports · 2014Article
- Comparative analysis of genome-wide chromosomal histone modification patterns in maize cultivars and their wild relatives.PloS one · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A simple cell model consisting of a gene regulatory network with epigenetic feedback regulation is studied to evaluate the effect of epigenetic dynamics on adaptation and evolution. We find that, the type of epigenetic dynamics considered enables a cell to adapt to unfamiliar environmental changes, for which no regulatory program has been prepared, through noise-driven selection of a cellular state with a high growth rate. Furthermore, we demonstrate that the inclusion of epigenetic regulation promotes evolutionary development of a regulatory network that can respond to environmental changes in a fast and precise manner. These results strongly suggest that epigenetic feedback regulation in gene expression dynamics provides a significant increase in fitness by engendering an increase in cellular plasticity during adaptation and evolution.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.