ArticleKorean journal of pathology2013
EBV-Positive T/NK-Cell Lymphoproliferative Disease of Childhood.
Article in Korean journal of pathology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 62 citations in OpenAlex.
- Histopathological characteristics of Epstein-Barr virus (EBV)-associated encephalitis and colitis in chronic active EBV infection.Journal of pathology and translational medicine · 2025Article
- Clinical epidemiology of Epstein-Barr virus-associated Lymphoproliferative Disorders (EBV-LPDs) in hospitalized children: A six-year multi-institutional study in China.Italian journal of pediatrics · 2024Article
- Hemophagocytic Lymphohistiocytosis in the Context of Hematological Malignancies and Solid Tumors.Advances in experimental medicine and biology · 2024Review
- The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: Lymphoid Neoplasms.Leukemia · 2022Review
- A rare B-cell type chronic active Epstein-Barr virus infection patient mimicking lymphoma onAmerican journal of nuclear medicine and molecular imaging · 2022Article
- Clinicopathologic findings of chronic active Epstein-Barr virus infection in adults: A single-center retrospective study in China.Clinical and experimental medicine · 2021Article
- Outcome of L-DEP regimen for treatment of pediatric chronic active Epstein-Barr virus infection.Orphanet journal of rare diseases · 2021Article
- Epstein-Barr virus NK and T cell lymphoproliferative disease: report of a 2018 international meeting.Leukemia & lymphoma · 2020Review
- Epstein-Barr Virus-Associated T and NK-Cell Lymphoproliferative Diseases.Frontiers in pediatrics · 2019Review
- A distinct subtype of Epstein-Barr virus-positive T/NK-cell lymphoproliferative disorder: adult patients with chronic active Epstein-Barr virus infection-like features.Haematologica · 2018Article
- EBV-Positive Lymphoproliferations of B- T- and NK-Cell Derivation in Non-Immunocompromised Hosts.Pathogens (Basel, Switzerland) · 2018Review
- EBV-positive T/NK lymphoproliferative diseases: analysis of prognostic factors for patients in China.International journal of clinical and experimental pathology · 2018Article
- T- and NK-Cell Lymphomas and Systemic Lymphoproliferative Disorders and the Immunodeficiency Setting: 2015 SH/EAHP Workshop Report-Part 4.American journal of clinical pathology · 2017Article
- Cutaneous EBV-related lymphoproliferative disorders.Seminars in diagnostic pathology · 2017Article
- Consensus recommendations for the diagnosis and management of hemophagocytic lymphohistiocytosis associated with malignancies.Haematologica · 2015Article
- An uncommon presentation of EBV-driven HLH. Primary or secondary? An ongoing dilemma.BMJ case reports · 2015Article
- The ambiguous boundary between EBV-related hemophagocytic lymphohistiocytosis and systemic EBV-driven T cell lymphoproliferative disorder.International journal of clinical and experimental pathology · 2014Review
- Fatal familial hemophagocytic lymphohistiocytosis with perforin gene (Autopsy & case reportsArticle
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEpstein-Barr virus (EBV)-associated hemophagocytic lymphohistiocytosis (HLH), EBV-positive systemic T-cell lymphoproliferative disease (STLPD) of childhood, and chronic active EBV (CAEBV) infection may develop after primary EBV infection. This study reviewed the clinicopathological spectrum of EBV-associated T- and natural killer (NK)-cell LPD, including STLPD and CAEBV infection, with an analysis of T-cell clonality.
methodsClinicopathological features of seven patients with EBV-associated HLH or STLPD and 12 patients with CAEBV infection were reviewed. Immunohistochemical staining and a T-cell receptor (TCR) gene rearrangement study were performed.
resultsSTLPD and EBV-positive HLH showed significantly overlapping clinicopathological findings. One patient with STLPD and one patient with EBV-positive HLH demonstrated moderate to severe atypia of the infiltrating lymphocytes, whereas the remaining patients lacked significant atypia. Twelve patients had CAEBV infection, four of whom suffered mosquito-bite hypersensitivity, five showed NK lymphocytosis, and one suffered hydroa vacciniforme. Infiltrating lymphocytes were predominantly small and devoid of atypia. Hemophagocytic histiocytosis was found in seven of 11 patients. Monoclonality was detected in three (50%) of the six patients with successful TCR gene analysis.
conclusionsEBV-positive HLH and STLPD share similar clinicopathological findings and may constitute a continuous spectrum of acute EBV-associated T- or NK-cell proliferative disorders. The distinction of EBV-positive T-cell LPD from EBV-positive HLH may be difficult during routine diagnoses because of the technical limitations of clonality assessment.
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