ArticleInternational journal of body composition research2013
Chemical-shift water-fat MRI of white adipose depots: inability to resolve cell size differences.
Article in International journal of body composition research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
4 citing papers in PubMed.
- Physiological, anthropometric parameters, and balance skill response of healthy bankers to fitness training.Journal of exercise rehabilitation · 2019Article
- Weight Cycling Increases Longevity Compared with Sustained Obesity in Mice.Obesity (Silver Spring, Md.) · 2018Article
- Association of proton density fat fraction in adipose tissue with imaging-based and anthropometric obesity markers in adults.International journal of obesity (2005) · 2018Article
- Fat-water MRI of a diet-induced obesity mouse model at 15.2T.Journal of medical imaging (Bellingham, Wash.) · 2016Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
purposeAdipocyte cell size varies among individuals and importantly, is inversely correlated with insulin sensitivity, and modifiable by weight loss or pharmaceutical agents. However, there are no non-invasive, in vivo methods for adipocyte cell size determination. Here we apply Chemical-Shift Water-Fat MRI to in vivo measures of subcutaneous (inguinal) and visceral (gonadal) white adipose tissue (WAT) to determine whether the fat-signal fraction (FF) is a sensitive indicator of adipocyte cell size. MATERIALS AND
methodsC57BL/6J male mice (8 weeks old) were singly housed and fed a low-fat diet, high-fat diet or very high-fat diet (
resultsMice fed with higher fat content diets gained significantly more body weight, fat and lean mass while maintaining higher energy intakes over the 8 weeks. There was no significant difference in fat fraction for either gonadal (
conclusionAlthough diet-induced obesity significantly increased the amount of fat mass, as well as mean and overall white adipocyte cell size, the CS-MRI measured fat fraction between groups were not significantly different. These results do not support the utility of CS-MRI measured FF for in vivo determination of adipocyte cell size.
Indexed as
Identifiers
23667321PMC3649013What OpenQuestion holds
Registered trials
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