ArticleJournal of immunology (Baltimore, Md. : 1950)2013
Viral antigen induces differentiation of Foxp3+ natural regulatory T cells in influenza virus-infected mice.
Article in Journal of immunology (Baltimore, Md. : 1950), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
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Who cites it
49 citing papers in PubMed.
- T-betThe FEBS journal · 2026Article
- Influenza vaccination post-COVID-19 expands vaccine-specific effector CD4 T-cells and Tregs under positive influence of host trained innate immunity.NPJ vaccines · 2025Article
- T Cell Responses to Influenza Infections in Cattle.Viruses · 2025Review
- BLIMP1 negatively regulates IL-2 signaling in T cells.Science advances · 2025Article
- Regulatory T cells restrict immunity and pathology in distal tissue sites following a localized infection.Mucosal immunology · 2024Article
- Regulatory T cells: Supporting lung homeostasis and promoting resolution and repair after lung injury.The international journal of biochemistry & cell biology · 2024Review
- Review
- Unique immune profiles in collaborative cross mice linked to survival and viral clearance upon infection.iScience · 2024Article
- Deciphering the developmental trajectory of tissue-resident Foxp3Frontiers in immunology · 2024Review
- A T follicular helper cell origin for T regulatory type 1 cells.Cellular & molecular immunology · 2023Article
- A SARS-CoV-2 NSP7 homolog of a Treg epitope suppresses CD4+ and CD8+ T cell memory responses.Frontiers in immunology · 2023Article
- Effects of life-stage and passive tobacco smoke exposure on pulmonary innate immunity and influenza infection in mice.Journal of toxicology and environmental health. Part A · 2022Article
- Virus-Specific Regulatory T Cells Persist as Memory in a Neurotropic Coronavirus Infection.Journal of immunology (Baltimore, Md. : 1950) · 2022Article
- Pathogenesis of Respiratory Viral and Fungal Coinfections.Clinical microbiology reviews · 2022Review
- Multi-omics association analysis reveals interactions between the oropharyngeal microbiome and the metabolome in pediatric patients with influenza A virus pneumonia.Frontiers in cellular and infection microbiology · 2022Article
- Local memory CD4 T cell niches in respiratory viral infection.The Journal of experimental medicine · 2021Article
- Article
- Computational investigations of the immune response to repeated influenza infections and vaccinations.Royal Society open science · 2021Article
- Susceptibility and Severity of Viral Infections in Obesity: Lessons from Influenza to COVID-19. Does Leptin Play a Role?International journal of molecular sciences · 2021Review
- An immune-based biomarker signature is associated with mortality in COVID-19 patients.JCI insight · 2021Article
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
We examined the formation, participation, and functional specialization of virus-reactive Foxp3(+) regulatory T cells (Tregs) in a mouse model of influenza virus infection. "Natural" Tregs generated intrathymically, based on interactions with a self-peptide, proliferated in response to a homologous viral Ag in the lungs and, to a lesser extent, in the lung-draining mediastinal lymph nodes (medLNs) of virus-infected mice. In contrast, conventional CD4(+) T cells with identical TCR specificity underwent little or no conversion to become "adaptive" Tregs. The virus-reactive Tregs in the medLNs and the lungs of infected mice upregulated a variety of molecules associated with Treg activation, as well as acquired expression of molecules (T-bet, Blimp-1, and IL-10) that confer functional specialization to Tregs. Notably, however, the phenotypes of the T-bet(+) Tregs obtained from these sites were distinct, because Tregs isolated from the lungs expressed significantly higher levels of T-bet, Blimp-1, and IL-10 than did Tregs from the medLNs. Adoptive transfer of Ag-reactive Tregs led to decreased proliferation of antiviral CD4(+) and CD8(+) effector T cells in the lungs of infected hosts, whereas depletion of Tregs had a reciprocal effect. These studies demonstrate that thymically generated Tregs can become activated by a pathogen-derived peptide and acquire discrete T-bet(+) Treg phenotypes while participating in and modulating an antiviral immune response.
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