ArticleJournal of immunology (Baltimore, Md. : 1950)2013
Total parenteral nutrition-associated lamina propria inflammation in mice is mediated by a MyD88-dependent mechanism.
Article in Journal of immunology (Baltimore, Md. : 1950), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
41 citing papers in PubMed, 81 citations in OpenAlex.
- Modulating gut microbial biofilms for intestinal barrier repair: opportunities in nutritional intervention.Frontiers in nutrition · 2026Review
- Decoding the gut interactome after severe trauma: from molecular dialogue to integrative treatment strategies.Frontiers in microbiology · 2026Review
- Friend or foe: the gut microbiota as a modulator of disease trajectory in trauma, surgery, and critical illness.Gut microbes · 2025Review
- Parenteral Nutrition, Inflammatory Bowel Disease, and Gut Barrier: An Intricate Plot.Nutrients · 2024Review
- Alterations of gut microbiome following gastrointestinal surgical procedures and their potential complications.Frontiers in cellular and infection microbiology · 2023Review
- Partially hydrolyzed guar gum alleviates hepatic steatosis and alters specific gut microbiota in a murine liver injury model.Pediatric surgery international · 2022Article
- Diet-derived metabolites and mucus link the gut microbiome to fever after cytotoxic cancer treatment.Science translational medicine · 2022Article
- Impact of Total Parenteral Nutrition on Gut Microbiota in Pediatric Population Suffering Intestinal Disorders.Nutrients · 2022Review
- The central and biodynamic role of gut microbiota in critically ill patients.Critical care (London, England) · 2022Review
- The Pathology and Physiology of Ileostomy.Frontiers in nutrition · 2022Review
- Nutritional modulation of the gut microbiome in allogeneic hematopoietic stem cell transplantation recipients.Frontiers in nutrition · 2022Review
- The effect of enteral stimulation on the immune response of the intestinal mucosa and its application in nutritional support.European journal of clinical nutrition · 2021Review
- Why is it worth remembering the lung microbiome in ICU patients?Anaesthesiology intensive therapy · 2021Review
- Mechanisms of Parenteral Nutrition-Associated Liver and Gut Injury.Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition · 2020Review
- Review
- Longitudinal changes in the gut microbiome of infants on total parenteral nutrition.Pediatric research · 2019Article
- The Effect of Butyrate-Supplemented Parenteral Nutrition on Intestinal Defence Mechanisms and the Parenteral Nutrition-Induced Shift in the Gut Microbiota in the Rat Model.BioMed research international · 2019Article
- Effects of Psychological, Environmental and Physical Stressors on the Gut Microbiota.Frontiers in microbiology · 2018Review
- Alterations in the Urinary Microbiota Are Associated With Cesarean Delivery.Frontiers in microbiology · 2018Article
- Metabolic programming of the epigenome: host and gut microbial metabolite interactions with host chromatin.Translational research : the journal of laboratory and clinical medicine · 2017Review
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
Enteral nutrient deprivation via total parenteral nutrition (TPN) administration leads to local mucosal inflammatory responses, but the underlying mechanisms are unknown. Wild-type (WT) and MyD88(-/-) mice underwent jugular vein cannulation. One group received TPN without chow, and controls received standard chow. After 7 d, we harvested intestinal mucosally associated bacteria and isolated small-bowel lamina propria (LP) cells. Bacterial populations were analyzed using 454 pyrosequencing. LP cells were analyzed using quantitative PCR and multicolor flow cytometry. WT, control mucosally associated microbiota were Firmicutes-dominant, whereas WT TPN mice were Proteobacteria-domiant. Similar changes were observed in MyD88(-/-) mice with TPN administration. UniFrac analysis showed divergent small bowel and colonic bacterial communities in controls, merging toward similar microbiota (but distinct from controls) with TPN. The percentage of LP T regulatory cells significantly decreased with TPN in WT mice. F4/80(+)CD11b(+)CD11c(dull/-) macrophage-derived proinflammatory cytokines significantly increased with TPN. These proinflammatory immunologic changes were significantly abrogated in MyD88(-/-) TPN mice. Thus, TPN administration is associated with significant expansion of Proteobacteria within the intestinal microbiota and increased proinflammatory LP cytokines. Additionally, MyD88 signaling blockade abrogated decline in epithelial cell proliferation and epithelial barrier function loss.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.