ArticleThe Journal of clinical endocrinology and metabolism2013
Expression and function of the progesterone receptor in human prostate stroma provide novel insights to cell proliferation control.
Article in The Journal of clinical endocrinology and metabolism, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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Who cites it
30 citing papers in PubMed.
- Novel hormone therapies for advanced prostate cancer: Understanding and countering drug resistance.Journal of pharmaceutical analysis · 2025Review
- Mechanistic insights into steroid hormone-mediated regulation of the androgen receptor gene.PloS one · 2024Article
- Trends in estrogen and progesterone receptors in prostate cancer: a bibliometric analysis.Frontiers in oncology · 2023Article
- Inhibiting 3βHSD1 to eliminate the oncogenic effects of progesterone in prostate cancer.Cell reports. Medicine · 2022Article
- PAQR6 Upregulation Is Associated with AR Signaling and Unfavorite Prognosis in Prostate Cancers.Biomolecules · 2021Article
- Oleuropein is a natural inhibitor of PAI-1-mediated proliferation in human ER-/PR- breast cancer cells.Breast cancer research and treatment · 2021Article
- Systemic distribution of progesterone receptor subtypes in human tissues.The Journal of steroid biochemistry and molecular biology · 2020Article
- Overcoming the mechanisms of primary and acquired resistance to new generation hormonal therapies in advanced prostate cancer: focus on androgen receptor independent pathways.Cancer drug resistance (Alhambra, Calif.) · 2020Review
- Current evidence for the involvement of sex steroid receptors and sex hormones in benign prostatic hyperplasia.Research and reports in urology · 2019Review
- Metastatic prostate cancer remains incurable, why?Asian journal of urology · 2019Review
- Alternative RNA splicing of the GIT1 gene is associated with neuroendocrine prostate cancer.Cancer science · 2019Article
- Review
- A novel mechanism of SRRM4 in promoting neuroendocrine prostate cancer development via a pluripotency gene network.EBioMedicine · 2018Article
- Progesterone Receptors in Prostate Cancer: Progesterone receptor B is the isoform associated with disease progression.Scientific reports · 2018Article
- Roles of Alternative RNA Splicing of the Bif-1 Gene by SRRM4 During the Development of Treatment-induced Neuroendocrine Prostate Cancer.EBioMedicine · 2018Article
- Loss of Nuclear Functions of HOXA10 Is Associated With Testicular Cancer Proliferation.Frontiers in oncology · 2018Article
- Article
- Alternative RNA splicing of the MEAF6 gene facilitates neuroendocrine prostate cancer progression.Oncotarget · 2017Article
- Androgen receptor targeted therapies in castration-resistant prostate cancer: Bench to clinic.International journal of urology : official journal of the Japanese Urological Association · 2016Review
- Differential expression of androgen, estrogen, and progesterone receptors in benign prostatic hyperplasia.Bosnian journal of basic medical sciences · 2016Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
contextLike other tissues, the prostate is an admixture of many different cell types that can be segregated into components of the epithelium or stroma. Reciprocal interactions between these 2 types of cells are critical for maintaining prostate homeostasis, whereas aberrant stromal cell proliferation can disrupt this balance and result in diseases such as benign prostatic hyperplasia. Although the androgen and estrogen receptors are relatively well studied for their functions in controlling stromal cell proliferation and differentiation, the role of the progesterone receptor (PR) remains unclear.
objectiveThe aim of the study was to investigate the expression and function of the PR in the prostate. DESIGN AND
settingHuman prostate biopsies, renal capsule xenografts, and prostate stromal cells were used. Immunohistochemistry, Western blotting, real-time quantitative PCR, cell proliferation, flow cytometry, and gene microarray analyses were performed.
resultsTwo PR isoforms, PRA and PRB, are expressed in prostate stromal fibroblasts and smooth muscle cells, but not in epithelial cells. Both PR isoforms suppress prostate stromal cell proliferation through inhibition of the expression of cyclinA, cyclinB, and cdc25c, thus delaying cell cycling through S and M phases. Gene microarray analyses further demonstrated that PRA and PRB regulated different transcriptomes. However, one of the major gene groups commonly regulated by both PR isoforms was the one associated with regulation of cell proliferation.
conclusionPR plays an inhibitory role in prostate stromal cell proliferation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.