ArticleJournal of biomedical materials research. Part A2014
Host response to microgel coatings on neural electrodes implanted in the brain.
Article in Journal of biomedical materials research. Part A, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed.
- Dynamic, Reconfigurable, and Hierarchical Biosynthetic Composites via Collagen Self-Assembly within Highly Crowded Microgel Pastes.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Fabrication and Dose-Response Simulation of Soft Dual-Sided Deep Brain Stimulation Electrode.Micromachines · 2025Article
- Deep Brain Stimulation in Advanced Parkinson's Disease: An Uncommon Case of Allergic Encephalitis.Journal of movement disorders · 2024Article
- Differential expression of genes involved in the chronic response to intracortical microelectrodes.Acta biomaterialia · 2023Article
- The effect of A1 and A2 reactive astrocyte expression on hydrocephalus shunt failure.Fluids and barriers of the CNS · 2022Article
- Clickable Biomaterials for Modulating Neuroinflammation.International journal of molecular sciences · 2022Review
- Flexible Neural Probes with Optical Artifact-Suppressing Modification and Biofriendly Polypeptide Coating.Micromachines · 2022Article
- A high-resolution real-time quantification of astrocyte cytokine secretion under shear stress for investigating hydrocephalus shunt failure.Communications biology · 2021Article
- Particle Stiffness and Surface Topography Determine Macrophage-Mediated Removal of Surface Adsorbed Particles.Advanced healthcare materials · 2021Article
- Electrical percolation in extrinsically conducting, poly(ε-decalactone) composite neural interface materials.Scientific reports · 2021Article
- Zwitterionic Polymer Coating Suppresses Microglial Encapsulation to Neural Implants In Vitro and In Vivo.Advanced biosystems · 2020Article
- Zwitterionic polymer/polydopamine coating reduce acute inflammatory tissue responses to neural implants.Biomaterials · 2019Article
- A novel neural electrode with micro-motion-attenuation capability based on compliant mechanisms-physical design concepts and evaluations.Medical & biological engineering & computing · 2018Article
- Planar coil-based contact-mode magnetic stimulation: synaptic responses in hippocampal slices and thermal considerations.Scientific reports · 2018Article
- Inhibition of the cluster of differentiation 14 innate immunity pathway with IAXO-101 improves chronic microelectrode performance.Journal of neural engineering · 2018Article
- A Materials Roadmap to Functional Neural Interface Design.Advanced functional materials · 2018Article
- Engineered Axonal Tracts as "Living Electrodes" for Synaptic-Based Modulation of Neural Circuitry.Advanced functional materials · 2018Article
- Biomaterial strategies for limiting the impact of secondary events following spinal cord injury.Biomedical materials (Bristol, England) · 2018Review
- Biomimetic extracellular matrix coatings improve the chronic biocompatibility of microfabricated subdural microelectrode arrays.PloS one · 2018Article
- Recent Advances in Neural Electrode-Tissue Interfaces.Current opinion in biomedical engineering · 2017Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
The performance of neural electrodes implanted in the brain is often limited by host response in the surrounding brain tissue, including astrocytic scar formation, neuronal cell death, and inflammation around the implant. We applied conformal microgel coatings to silicon neural electrodes and examined host responses to microgel-coated and uncoated electrodes following implantation in the rat brain. In vitro analyses demonstrated significantly reduced astrocyte and microglia adhesion to microgel-coated electrodes compared to uncoated controls. Microgel-coated and uncoated electrodes were implanted in the rat brain cortex and the extent of activated microglia and astrocytes as well as neuron density around the implant were evaluated at 1, 4, and 24 weeks postimplantation. Microgel coatings reduced astrocytic recruitment around the implant at later time points. However, microglial response indicated persistence of inflammation in the area around the electrode. Neuronal density around the implanted electrodes was also lower for both implant groups compared to the uninjured control. These results demonstrate that microgel coatings do not significantly improve host responses to implanted neural electrodes and underscore the need for further improvements in implantable materials.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.