ReviewCurrent diabetes reports2013
Corneal confocal microscopy: a new technique for early detection of diabetic neuropathy.
Review in Current diabetes reports, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02423434 (Multinational Collaborative Evaluation of Corneal Confocal Microscopy as a Surrogate Endpoint for the Identification and Prediction of Diabetic Neuropathy in Type 1 Diabetes), which is not on this map. Cited by 35 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Multinational Collaborative Evaluation of Corneal Confocal Microscopy as a Surrogate Endpoint for the Identification and Prediction of Diabetic Neuropathy in Type 1 Diabetes
Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it, 68 citations in OpenAlex.
- Performance analysis of noninvasive electrophysiological methods for the assessment of diabetic sensorimotor polyneuropathy in clinical research: a systematic review and meta-analysis with trial sequential analysis.Scientific reports · 2020Pooled it
- Non-invasive biomarkers for diabetic complications: insights from corneal and retinal imaging.Acta diabetologica · 2026Article
- SuperCCM: An Open Source Python Toolkit for Automated Quantification of Corneal Nerve Fibers in Confocal Microscopy Images.Translational vision science & technology · 2025Article
- Diabetic corneal neuropathy as a surrogate marker for diabetic peripheral neuropathy.Neural regeneration research · 2022Review
- Corneal confocal microscopy in patients with distal symmetric polyneuropathy compared to controls.Arquivos de neuro-psiquiatria · 2022Article
- Diabetes Distal Peripheral Neuropathy: Subtypes and Diagnostic and Screening Technologies.Journal of diabetes science and technology · 2022Review
- Performance Analysis of Conventional Machine Learning Algorithms for Diabetic Sensorimotor Polyneuropathy Severity Classification Using Nerve Conduction Studies.Computational intelligence and neuroscience · 2022Article
- Differential effects of obstructive sleep apnea on the corneal subbasal nerve plexus and retinal nerve fiber layer.PloS one · 2022Article
- Systemic diseases and the cornea.Experimental eye research · 2021Review
- Tear Levels of IGFBP-3: A Potential Biomarker for Diabetic Nerve Changes in the Cornea.Eye & contact lens · 2020Review
- An unbiased stereological method for corneal confocal microscopy in patients with diabetic polyneuropathy.Scientific reports · 2020Article
- Tear biomarkers and corneal sensitivity as an indicator of neuropathy in type 2 diabetes.Diabetes research and clinical practice · 2020Article
- Progressive Loss of Corneal Nerve Fibers and Sensitivity in Rats Modeling Obesity and Type 2 Diabetes Is Reversible with Omega-3 Fatty Acid Intervention: Supporting Cornea Analyses as a Marker for Peripheral Neuropathy and Treatment.Diabetes, metabolic syndrome and obesity : targets and therapy · 2020Article
- Current Diagnosis and Treatment of Painful Small Fiber Neuropathy.Current neurology and neuroscience reports · 2019Review
- Corneal injury: Clinical and molecular aspects.Experimental eye research · 2019Review
- Contact lens wear and the diabetic corneal epithelium: A happy or disastrous marriage?Journal of diabetes and its complications · 2019Review
- In Vivo Corneal Confocal Microscopy Detects Improvement of Corneal Nerve Parameters following Glycemic Control in Patients with Type 2 Diabetes.Journal of diabetes research · 2018Article
- Diabetic complications in the cornea.Vision research · 2017Review
- Declining Skeletal Muscle Function in Diabetic Peripheral Neuropathy.Clinical therapeutics · 2017Review
- Early vs. late intervention of high fat/low dose streptozotocin treated C57Bl/6J mice with enalapril, α-lipoic acid, menhaden oil or their combination: Effect on diabetic neuropathy related endpoints.Neuropharmacology · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Corneal confocal microscopy (CCM) is a noninvasive method for the study of human cornea in vivo. It has increasingly been used to assess the morphology of the sub-basal corneal nerve plexus. CCM has good reproducibility and may contribute to the early diagnosis of diabetic polyneuropathy. It may also be useful to document favorable changes in nerve fiber structure early after therapeutic intervention. Corneal nerve pathology is more pronounced in patients with diabetic polyneuropathy and is associated with its clinical severity. The sensitivity and specificity of CCM for the diagnosis of polyneuropathy is moderate to high. CCM now merits further use in large longitudinal studies to provide more information on the natural history of diabetic neuropathy and effects of treatment. Moreover, there is a need for a larger normative database. Finally, technical progress is expected to enable visualization of larger corneal areas and improve nerve fiber quantification, increasing diagnostic accuracy.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.