ArticleGenome biology and evolution2013
A large pseudoautosomal region on the sex chromosomes of the frog Silurana tropicalis.
Article in Genome biology and evolution, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 31 citations in OpenAlex.
- Genome-Wide Characterization of Sex-Linked Regions in the Sangzhi Horned Toad (Boulenophrys sangzhiensis) Reveals Complex Sex Determination Mechanisms.Molecular ecology resources · 2026Article
- Persistence of an unusual triple sex chromosome system through allopolyploidization in African clawed frogs (Xenopus, subgenus Silurana).Evolution; international journal of organic evolution · 2026Article
- Sex chromosome cycle as a mechanism of stable sex determination.Journal of biochemistry · 2024Review
- A brief review of vertebrate sex evolution with a pledge for integrative research: towards 'Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2021Review
- RADSex: A computational workflow to study sex determination using restriction site-associated DNA sequencing data.Molecular ecology resources · 2021Article
- Amplified Fragments of an Autosome-Borne Gene Constitute a Significant Component of the W Sex Chromosome ofGenes · 2021Article
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- A frog with three sex chromosomes that co-mingle together in nature: Xenopus tropicalis has a degenerate W and a Y that evolved from a Z chromosome.PLoS genetics · 2020Article
- Sex is determined by XY chromosomes across the radiation of dioeciousEvolution letters · 2019Article
- Sequential Turnovers of Sex Chromosomes in African Clawed Frogs (G3 (Bethesda, Md.) · 2016Article
- Dynamics of vertebrate sex chromosome evolution: from equal size to giants and dwarfs.Chromosoma · 2016Review
- Sex determination by multiple sex chromosomes in Xenopus tropicalis.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Coexistence of Y, W, and Z sex chromosomes in Xenopus tropicalis.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
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Authors and funding
14 authors at 5 institutions in 4 countries.
Funding
Abstract
Sex chromosome divergence has been documented across phylogenetically diverse species, with amphibians typically having cytologically nondiverged ("homomorphic") sex chromosomes. With an aim of further characterizing sex chromosome divergence of an amphibian, we used "RAD-tags" and Sanger sequencing to examine sex specificity and heterozygosity in the Western clawed frog Silurana tropicalis (also known as Xenopus tropicalis). Our findings based on approximately 20 million genotype calls and approximately 200 polymerase chain reaction-amplified regions across multiple male and female genomes failed to identify a substantially sized genomic region with genotypic hallmarks of sex chromosome divergence, including in regions known to be tightly linked to the sex-determining region. We also found that expression and molecular evolution of genes linked to the sex-determining region did not differ substantially from genes in other parts of the genome. This suggests that the pseudoautosomal region, where recombination occurs, comprises a large portion of the sex chromosomes of S. tropicalis. These results may in part explain why African clawed frogs have such a high incidence of polyploidization, shed light on why amphibians have a high rate of sex chromosome turnover, and raise questions about why homomorphic sex chromosomes are so prevalent in amphibians.
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