ReviewJournal of cardiovascular translational research2013
Positioning of inflammatory biomarkers in the heart failure landscape.
Review in Journal of cardiovascular translational research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04130243 (Biomarkers in Congenital Heart Diseases and Pulmonary Arterial Hypertension), which is not on this map. Cited by 36 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Biomarkers in Congenital Heart Diseases and Pulmonary Arterial Hypertension
Who cites it
36 citing papers in PubMed, 4 syntheses or guidelines pooled it, 79 citations in OpenAlex.
- Xinmailong injection on left ventricular remodeling and inflammatory mediators in patients with CHF: a systematic review and meta-analysis.Frontiers in pharmacology · 2024Pooled it
- Effect of aerobic and resistance training on inflammatory markers in heart failure patients: systematic review and meta-analysis.Heart failure reviews · 2018Pooled it
- Diagnostic Value of Soluble Suppression of Tumorigenicity-2 for Heart Failure.Chinese medical journal · 2016Pooled it
- Vitamin D Supplementation in the Treatment of Chronic Heart Failure: A Meta-analysis of Randomized Controlled Trials.Clinical cardiology · 2016Pooled it
- Pro-Inflammatory Biomarkers in Stable Versus Acutely Decompensated Heart Failure With Preserved Ejection Fraction.Journal of the American Heart Association · 2018Trial
- Reframing Heart Failure as a Multiorgan Network Disorder: Translational and Regenerative Perspectives in Veterinary Cardiology.Veterinary sciences · 2026Review
- Proteomic-based biomarker discovery reveals panels of diagnostic biomarkers for early identification of heart failure subtypes.Journal of translational medicine · 2025Article
- Improving effect of physical exercise on heart failure: Reducing oxidative stress-induced inflammation by restoring CaMolecular and cellular biochemistry · 2025Review
- Screening of Secretory Proteins Linking Major Depressive Disorder with Heart Failure Based on Comprehensive Bioinformatics Analysis and Machine Learning.Biomolecules · 2024Article
- Functions and Clinical Significance of Myocardial Cell-Derived Immunoglobulins.Advances in experimental medicine and biology · 2024Review
- Harnessing the Plasma Proteome to Mirror Current and Predict Future Cardiac Remodeling After Myocardial Infarction.Journal of cardiovascular translational research · 2023Article
- Role of Distinct Macrophage Populations in the Development of Heart Failure in Macrophage Activation Syndrome.International journal of molecular sciences · 2022Review
- CMV Infection Is Directly Related to the Inflammatory Status in Chronic Heart Failure Patients.Frontiers in immunology · 2021Article
- Various aspects of inflammation in heart failure.Heart failure reviews · 2020Review
- Association of soluble interleukin-2 receptor α and tumour necrosis factor receptor 1 with heart failure: The Multi-Ethnic Study of Atherosclerosis.ESC heart failure · 2020Article
- Vagus Nerve Stimulation and the Cardiovascular System.Cold Spring Harbor perspectives in medicine · 2020Review
- Biomarkers in heart failure: the past, current and future.Heart failure reviews · 2019Review
- Cardiomyopathy Associated with Diabetes: The Central Role of the Cardiomyocyte.International journal of molecular sciences · 2019Review
- Association between inflammation-based prognostic scores and in-hospital outcomes in elderly patients with acute myocardial infarction.Clinical interventions in aging · 2019Article
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The clinical syndrome of heart failure is characterized by a systemic inflammatory response that contributes to end organ damage in the heart and circulation and can thus lead to worsening heart failure. The ensemble of inflammatory mediators that have been detected in heart failure patients include pro-inflammatory cytokines and their cognate receptors, as well as molecules secreted/released by macrophages (galectin-3 and pentraxin-3). Inflammatory biomarkers correlate with disease severity and prognosis across the broad spectrum of heart failure syndromes. Given the proliferation of new biomarkers that predict disease severity and prognosis in heart failure, it is reasonable to ask whether there is a current role for measuring inflammatory mediators in heart failure. This review will attempt to address this question, as well as review several novel approaches that have utilized inflammatory biomarkers to enhance risk stratification and prognosis in heart failure patients.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.