ArticleJournal of pediatric gastroenterology and nutrition2013
Aspartate aminotransferase to platelet ratio index correlates with hepatic cirrhosis but not with fibrosis in pediatric patients with intestinal failure.
Article in Journal of pediatric gastroenterology and nutrition, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 37 citations in OpenAlex.
- Prediction of hepatic fibrosis using the aspartate transaminase-to-platelet ratio index in children and adolescents with metabolic dysfunction-associated steatotic liver disease.BMC pediatrics · 2024Article
- Long-term follow-up of biliary atresia using liver transient elastography.Pediatric surgery international · 2022Article
- A Limited Course of Eculizumab in a Child with the Atypical Hemolytic Uremic Syndrome and Pre-B Acute Lymphoblastic Leukemia on Maintenance Therapy: Case Report and Literature Review.Journal of clinical medicine · 2022Article
- IFALD in children: What's new? A narrative review.Frontiers in nutrition · 2022Review
- Fish Oil Emulsion Reduces Liver Injury and Liver Transplantation in Children with Intestinal Failure-Associated Liver Disease: A Multicenter Integrated Study.The Journal of pediatrics · 2021Article
- Biopsy Validated Study of Biomarkers for Liver Fibrosis and Transplant Prediction in Inherited Cholestasis.Hepatology communications · 2020Article
- Serum Scoring and Quantitative Magnetic Resonance Imaging in Intestinal Failure-Associated Liver Disease: A Feasibility Study.Nutrients · 2020Article
- Assessment of Selected Parameters of Liver Fibrosis and Inflammation in Patients with Diagnosed Cystic Fibrosis.Mediators of inflammation · 2020Article
- AST-to-Platelet Ratio Index as Potential Early-Warning Biomarker for Sepsis-Associated Liver Injury in Children: A Database Study.Frontiers in pediatrics · 2019Article
- Limitations and opportunities of non-invasive liver stiffness measurement in children.World journal of hepatology · 2017Review
- Packed red blood cell transfusions as a risk factor for parenteral nutrition associated liver disease in premature infants.World journal of clinical pediatrics · 2016Article
- Acoustic radiation force impulse sonography in assessing children with biliary atresia for liver transplantation.Pediatric radiology · 2016Article
- Enteral autonomy, cirrhosis, and long term transplant-free survival in pediatric intestinal failure patients.Journal of pediatric surgery · 2016Article
- Contribution of acoustic radiation force impulse (ARFI) elastography to the ultrasound diagnosis of biliary atresia.Pediatric radiology · 2015Article
- Predictors of Enteral Autonomy in Children with Intestinal Failure: A Multicenter Cohort Study.The Journal of pediatrics · 2015Article
- Validation of aspartate aminotransferase to platelet ratio for diagnosis of liver fibrosis and prediction of postoperative prognosis in infants with biliary atresia.World journal of gastroenterology · 2015Article
- Preservation of biochemical liver function with low-dose soy-based lipids in children with intestinal failure-associated liver disease.Journal of pediatric gastroenterology and nutrition · 2015Article
- Role of the Aspartate Transaminase and Platelet Ratio Index in Assessing Hepatic Fibrosis and Liver Inflammation in Adolescent Patients with HBeAg-Positive Chronic Hepatitis B.Gastroenterology research and practice · 2015Article
- Serum Inter-Alpha-Trypsin Inhibitor Heavy Chain 4 (ITIH4) in Children with Chronic Hepatitis C: Relation to Liver Fibrosis and Viremia.Hepatitis research and treatment · 2014Article
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Authors and funding
7 authors at 3 institutions in 3 countries.
Funding
Abstract
BACKGROUND AND
objectivesPatients with intestinal failure (IF) require parenteral nutrition (PN) support to obtain enough nutrients to sustain growth; long-term PN use is associated with significant liver damage. The aim of this study was to analyze the use of a noninvasive test, the aspartate aminotransferase to platelet ratio index (APRI), in the diagnosis of liver disease in pediatric patients with IF.
methodsMedical records of all Boston Children's Hospital patients who received PN and underwent a liver biopsy from January 2006 until November 2010 were reviewed. Patients with IF with a clinical diagnosis were selected. APRI was calculated as (aspartate aminotransferase [U/L]/upper normal limit) × 100/platelets (10(9) cells/L). Presence of fibrosis and cirrhosis was estimated using the METAVIR score in liver biopsies.
resultsSixty-two liver biopsies from 48 patients (22 girls) were studied. Mean APRI values in the different METAVIR categories (0-1, 2-3, 4) were 1.80, 1.17, and 4.24, respectively (analysis of variance P = 0.053; Bonferroni test for cirrhosis vs fibrosis P = 0.048). APRI could significantly predict cirrhosis (odds ratio 1.2; 95% confidence interval [CI] 1.001-1.43) but not fibrosis (METAVIR 2-3, odds ratio 1.00; 95% CI 0.86-1.18). Area under the receiver operating characteristic curve for cirrhosis was 0.67 (95% CI 0.45-0.89; P = 0.13).
conclusionsAPRI, a noninvasive, easy-to-obtain bedside test, significantly predicts cirrhosis but not fibrosis in pediatric patients with IFALD. Because the clinicians need a noninvasive test to differentiate among different stages of liver fibrosis rather than differentiating cirrhosis from normal, we cannot recommend the use of this test in pediatric patients with IFALD for this purpose.
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