ArticleNaunyn-Schmiedeberg's archives of pharmacology2013
Intravenous infusion of ascorbic acid decreases serum histamine concentrations in patients with allergic and non-allergic diseases.
Article in Naunyn-Schmiedeberg's archives of pharmacology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 67 citations in OpenAlex.
- Effect of antioxidants on histamine receptor activation and sustained postexercise vasodilatation in humans.Experimental physiology · 2015Trial
- The Role of hCG and Histamine in Emesis Gravidarum and Use of a Chewing Gum Containing Vitamin C as a Treatment Option: A Double-Blinded, Randomized, Controlled Trial.Journal of clinical medicine · 2024Article
- The Effect of Vitamins on the Immune Systems of Pigs.Animals : an open access journal from MDPI · 2024Review
- Cluster-Analytic Identification of Clinically Meaningful Subtypes in MCAS: The Relevance of Heat and Cold.Digestive diseases and sciences · 2023Article
- The Role of Nutrients in Prevention, Treatment and Post-Coronavirus Disease-2019 (COVID-19).Nutrients · 2022Review
- The Complex Interplay between Immunonutrition, Mast Cells, and Histamine Signaling in COVID-19.Nutrients · 2021Review
- Dietary Supplements and Nutraceuticals under Investigation for COVID-19 Prevention and Treatment.mSystems · 2021Review
- Mast Cell Activation Syndrome: A Primer for the Gastroenterologist.Digestive diseases and sciences · 2021Review
- Notable Developments for Vitamin D Amid the COVID-19 Pandemic, but Caution Warranted Overall: A Narrative Review.Nutrients · 2021Review
- Dietary Supplements and Nutraceuticals Under Investigation for COVID-19 Prevention and Treatment.ArXiv · 2021Article
- The Influence of Nutritional Factors on Immunological Outcomes.Frontiers in immunology · 2021Review
- Physical Activity and Natural Products and Minerals in the SARS-CoV-2 Pandemic: An Update.Annals of applied sport science · 2021Article
- Repositioning Vitamin C as a Promising Option to Alleviate Complications associated with COVID-19.Infection & chemotherapy · 2020Review
- The Study of Dried Ginger and Linggan Wuwei Jiangxin Decoction Treatment of Cold Asthma Rats Using GC-MS Based Metabolomics.Frontiers in pharmacology · 2019Article
- Hydrocortisone, Ascorbic Acid and Thiamine (HAT Therapy) for the Treatment of Sepsis. Focus on Ascorbic Acid.Nutrients · 2018Review
- Intravenous vitamin C in the treatment of allergies: an interim subgroup analysis of a long-term observational study.The Journal of international medical research · 2018Observational
- Idiopathic Mast Cell Activation Syndrome With Associated Salicylate Intolerance.Frontiers in pediatrics · 2018Article
- Plasma concentrations of ascorbic acid in a cross section of the German population.The Journal of international medical research · 2018Article
- Vitamin C andFrontiers in physiology · 2018Review
- Anti-Allergic Activity of Monoacylated Ascorbic Acid 2-Glucosides.Molecules (Basel, Switzerland) · 2017Article
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Histamine plays an important role in the development of symptoms in allergic, infectious, neoplastic and other diseases. Empirical findings have suggested beneficial effects of ascorbic acid supplementation in those diseases, and these effects are assumed to be related to a possible decrease in systemic histamine concentration. In the present study, we systematically investigated for the first time the effect of 7.5 g of intravenously administered ascorbic acid on serum histamine levels (as detected by ELISA) in 89 patients (19 with allergic and 70 with infectious diseases). When all patients were grouped together, there was a significant decline in histamine concentration from 0.83 to 0.57 ng/ml×m2 body surface area (BSA, p<0.0001). The decrease in serum histamine concentration in patients with allergic diseases (1.36 to 0.69 ng/ml×m2 BSA, p=0.0007) was greater than that in patients with infectious diseases (0.73 to 0.56 ng/ml×m2 BSA, p=0.01). Furthermore, the decline in histamine concentration after ascorbic acid administration was positively correlated with the basal, i.e. pre-therapeutic, histamine concentration. Intravenous infusion of ascorbic acid clearly reduced histamine concentrations in serum, and may represent a therapeutic option in patients presenting with symptoms and diseases associated with pathologically increased histamine concentration.
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