ArticleKnee surgery, sports traumatology, arthroscopy : official journal of the ESSKA2014
Implantation of tissue-engineered cartilage-like tissue for the treatment for full-thickness cartilage defects of the knee.
Article in Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
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Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it, 55 citations in OpenAlex.
- Cartilage failures. Systematic literature review, critical survey analysis, and definition.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2015Pooled it
- Trial
- Qualitative and Quantitative Evaluation of Loose Bodies as a Novel Cell Source for Autologous Chondrocyte Implantation.Orthopaedic journal of sports medicine · 2026Article
- Multimodal evaluation of periosteal versus collagen membrane coverage in atelocollagen-associated autologous chondrocyte implantation for large knee cartilage defects.Journal of experimental orthopaedics · 2026Article
- Clinical Effectiveness and Magnetic Resonance Imaging-Based Endurability of Matrix-Associated Autologous Chondrocyte Implantation with an Autologous Periosteal Flap for Articular Cartilage Defects of the Knee Joint.Journal of clinical medicine · 2026Article
- Article
- Latest Advances in Chondrocyte-Based Cartilage Repair.Biomedicines · 2024Review
- Comparative study on clinical outcomes in autologous chondrocyte implantation using three-dimensional cultured JACCScientific reports · 2024Article
- A Novel Approach for Multiple Material Extrusion in Arthroscopic Knee Surgery.Annals of biomedical engineering · 2023Article
- Good healing potential of patellar chondral defects after all-arthroscopic autologous chondrocyte implantation with spheroids: a second-look arthroscopic assessment.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2022Article
- Effect of Platelet-Rich Plasma on Autologous Chondrocyte Implantation for Chondral Defects: Results Using an In Vivo Rabbit Model.Orthopaedic journal of sports medicine · 2022Article
- Biomechanical Changes of Repair Tissue after Autologous Chondrocyte Implantation at Long-Term Follow-Up.Cartilage · 2021Article
- Bioprinting of Cartilage with Bioink Based on High-Concentration Collagen and Chondrocytes.International journal of molecular sciences · 2021Article
- Accurate Reporting of Concomitant Procedures Is Highly Variable in Studies Investigating Knee Cartilage Restoration.Cartilage · 2021Article
- The Benefit of Minced Cartilage Over Isolated Chondrocytes in Atelocollagen Gel on Chondrocyte Proliferation and Migration.Cartilage · 2021Article
- Large osteochondral defect in the lateral femoral condyle reconstructed by Atelocollagen-associated autologous chondrocyte implantation combined with anterior cruciate ligament reconstruction.BMC musculoskeletal disorders · 2020Article
- Autologous chondrocyte implantation with a Reveille cartilage processor for articular cartilage injury: a case report.Journal of surgical case reports · 2020Article
- Proliferation medium in three-dimensional culture of auricular chondrocytes promotes effective cartilage regenerationRegenerative therapy · 2019Article
- Effects of culture conditions on the mechanical and biological properties of engineered cartilage constructed with collagen hybrid scaffold and human mesenchymal stem cells.Journal of materials science. Materials in medicine · 2019Article
- A large knee osteochondral lesion treated using a combination of osteochondral autograft transfer and second-generation autologous chondrocyte implantation: A case report.Regenerative therapy · 2019Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe purposes of this study were to evaluate early- to midterm clinical results after implantation of tissue-engineered cartilage-like tissue for the treatment for full-thickness cartilage defects of the knee and to identify the factors affecting the final clinical results.
methodsTissue-engineered cartilage-like tissue was prepared by culturing autologous chondrocytes in atelocollagen gel for 3-4 weeks. A total of 73 knees of 72 patients with full-thickness cartilage defects were implanted with this tissue-engineered cartilage-like tissue. The follow-up of these patients for >5 years (range 5-11 years, median 8.0 years) is reported. The patients were evaluated clinically using a rating scale, as well as arthroscopically, biomechanically, and histologically. A modified magnetic resonance observation of cartilage repair tissue (MOCART) system was used to quantify the magnetic resonance imaging (MRI) findings of the lesions. The patient or defect factors influencing the final clinical outcomes were also investigated.
resultsClinical rating improved significantly after implantation of tissue-engineered cartilage-like tissue. Arthroscopic findings at 2 years after implantation were graded as normal or nearly normal according to the International Cartilage Repair Society (ICRS) scale in 64 of 73 knees (87.7%). Biomechanically, stiffness of the graft almost equalled the surrounding normal cartilage (87.9-102.5%) at 2 years after implantation. Histologically, overall assessment of the repaired tissue by ICRS Visual Assessment Scale II was 70.4 ± 20.8. The average MOCART score was 13.5 ± 11.3 (0-45) preoperatively, 66.6 ± 16.8 (10-90) at 1 year after implantation, 70.4 ± 16.1 (15-90) at 2 years after implantation, and 72.5 ± 17.4 (15-95) at the final follow-up, indicating that MRI results were maintained. Among the factors investigated, only arthroscopic grade of the repaired lesion at 2 years after implantation was significantly correlated with the final clinical scores.
conclusionsImplantation of tissue-engineered cartilage-like tissue for the cartilage defects of the knee was effective in short- to midterm post-operatively. This procedure can be proposed as one option for repairing full-thickness cartilage defect of the knee. LEVEL OF EVIDENCE: IV.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.