ArticleNature neuroscience2013
Selective and graded coding of reward uncertainty by neurons in the primate anterodorsal septal region.
Article in Nature neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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Who cites it
45 citing papers in PubMed.
- Sustained visual signals in the primate cerebellar dentate nucleus drive associative learning.Communications biology · 2025Article
- Dynamic coding and sequential integration of multiple reward attributes by primate amygdala neurons.Nature communications · 2025Article
- A reduced perception of sensory information is linked with elevated boredom in people with and without attention-deficit hyperactivity disorder.Communications psychology · 2025Article
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- Curiosity: primate neural circuits for novelty and information seeking.Nature reviews. Neuroscience · 2024Review
- An opponent striatal circuit for distributional reinforcement learning.bioRxiv : the preprint server for biology · 2024Article
- Modeling fashion as an emergent collective behavior of bored individuals.Scientific reports · 2023Article
- Studying the neural representations of uncertainty.Nature neuroscience · 2023Review
- Weaker situations: Uncertainty reveals individual differences in learning: Implications for PTSD.Cognitive, affective & behavioral neuroscience · 2023Review
- Rewarding-unrewarding prediction signals under a bivalent context in the primate lateral hypothalamus.Scientific reports · 2023Article
- Uncertainty modulates visual maps during noninstrumental information demand.Nature communications · 2022Article
- Neural population clocks: Encoding time in dynamic patterns of neural activity.Behavioral neuroscience · 2022Article
- Seeking motivation and reward: Roles of dopamine, hippocampus, and supramammillo-septal pathway.Progress in neurobiology · 2022Article
- Child witness expressions of certainty are informative.Journal of experimental psychology. General · 2021Article
- A prefrontal network integrates preferences for advance information about uncertain rewards and punishments.Neuron · 2021Article
- Common coding of expected value and value uncertainty memories in the prefrontal cortex and basal ganglia output.Science advances · 2021Article
- Non-human primates use combined rules when deciding under ambiguity.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2021Article
- Environment-based object values learned by local network in the striatum tail.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Reward uncertainty asymmetrically affects information transmission within the monkey fronto-parietal network.Communications biology · 2020Article
- How Outcome Uncertainty Mediates Attention, Learning, and Decision-Making.Trends in neurosciences · 2020Review
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Abstract
Natural environments are uncertain. Uncertainty of emotional outcomes can induce anxiety and raise vigilance, promote and signal the opportunity for learning, modulate economic choice and regulate risk-seeking. Here we demonstrate that a subset of neurons in the anterodorsal region of the primate septum (ADS) are primarily devoted to processing uncertainty in a highly specific manner. Those neurons were selectively activated by visual cues indicating probabilistic delivery of reward (for example, 25%, 50% and 75% reward) and did not respond to cues indicating certain outcomes (0% and 100% reward). The average ADS uncertainty response was graded with the magnitude of reward uncertainty and selectively signaled uncertainty about rewards rather than punishments. The selective and graded information about reward uncertainty encoded by many neurons in the ADS may underlie modulation of uncertainty of value- and sensorimotor-related areas to regulate goal-directed behavior.
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