ArticleInflammatory bowel diseases2013
Multidimensional prognostic risk assessment identifies association between IL12B variation and surgery in Crohn's disease.
Article in Inflammatory bowel diseases, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 3 of them syntheses that pooled it.
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Who cites it
22 citing papers in PubMed, 3 syntheses or guidelines pooled it, 43 citations in OpenAlex.
- Trans-ancestry, Bayesian meta-analysis discovers 20 novel risk loci for inflammatory bowel disease in an African American, East Asian and European cohort.Human molecular genetics · 2023Pooled it
- ACG Clinical Guideline: Management of Crohn's Disease in Adults.The American journal of gastroenterology · 2018Guideline
- Glycosylation of Immunoglobulin G Associates With Clinical Features of Inflammatory Bowel Diseases.Gastroenterology · 2018Pooled it
- Review
- Next-generation non-animal models for inflammatory bowel disease:NAM journal · 2025Review
- Global geoepidemiology of gastrointestinal surgery rates in Crohn's disease.World journal of gastrointestinal surgery · 2024Article
- Modern drug discovery for inflammatory bowel disease: The role of computational methods.World journal of gastroenterology · 2023Review
- Impact of Genes and the Environment on the Pathogenesis and Disease Course of Inflammatory Bowel Disease.Digestive diseases and sciences · 2019Review
- Development of Clinical Prediction Models for Surgery and Complications in Crohn's Disease.Journal of Crohn's & colitis · 2018Article
- Increased expression of IL12B mRNA transcribed from the risk haplotype for Crohn's disease is a risk factor for disease relapse in Japanese patients.Journal of gastroenterology · 2017Article
- IBD: Genetic differences in Crohn's disease susceptibility and outcome.Nature reviews. Gastroenterology & hepatology · 2017Article
- Biomarkers in Search of Precision Medicine in IBD.The American journal of gastroenterology · 2016Review
- Genetic variation in IBD: progress, clues to pathogenesis and possible clinical utility.Expert review of clinical immunology · 2016Review
- A Personalized Approach to Managing Inflammatory Bowel Disease.Gastroenterology & hepatology · 2016Article
- Genetics of Inflammatory Bowel Diseases.Gastroenterology · 2015Review
- The use of prognostic factors in inflammatory bowel diseases.Current gastroenterology reports · 2014Review
- Current issues of pediatric inflammatory bowel disease in Korea.Korean journal of pediatrics · 2014Review
- Personalized Medicine in Inflammatory Bowel Disease.Gastroenterology & hepatology · 2014Article
- Genetic studies of Crohn's disease: past, present and future.Best practice & research. Clinical gastroenterology · 2014Review
- In the pipeline.Gastroenterology & hepatology · 2014Article
Corrections and comments
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Authors and funding
22 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundThe ability to identify patients with Crohn's disease (CD) at highest risk of surgery would be invaluable in guiding therapy. Genome-wide association studies have identified multiple IBD loci with unknown phenotypic consequences. The aims of this study were to: (1) identify associations between known and novel CD loci with early resective CD surgery and (2) develop the best predictive model for time to surgery using a combination of phenotypic, serologic, and genetic variables.
methodsGenotyping was performed on 1,115 subjects using Illumina-based genome-wide technology. Univariate and multivariate analyses tested genetic associations with need for surgery within 5 years. Analyses were performed by testing known CD loci (n = 71) and by performing a genome-wide association study. Time to surgery was analyzed using Cox regression modeling. Clinical and serologic variables were included along with genotype to build predictive models for time to surgery.
resultsSurgery occurred within 5 years in 239 subjects at a median time of 12 months. Three CD susceptibility loci were independently associated with surgery within 5 years (IL12B, IL23R, and C11orf30). Genome-wide association identified novel putative loci associated with early surgery: 7q21 (CACNA2D1) and 9q34 (RXRA, COL5A1). The most predictive models of time to surgery included genetic and clinical risk factors. More than a 20% difference in frequency of progression to surgery was seen between the lowest and highest risk groups.
conclusionsProgression to surgery is faster in patients with CD with both genetic and clinical risk factors. IL12B is independently associated with need and time to early surgery in CD patients and justifies the investigation of novel and existing therapies that affect this pathway.
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Registered trials
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