ArticleThe EMBO journal2013
Attenuation of insulin signalling contributes to FSN-1-mediated regulation of synapse development.
Article in The EMBO journal, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- Identification of potential microRNAs and KEGG pathways in denervation muscle atrophy based on meta-analysis.Scientific reports · 2021Pooled it
- Three muscle-specific DAF-16/FOXO transcriptional targets activated by reduced insulin/IGF-1 signaling.G3 (Bethesda, Md.) · 2026Article
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- ADAR-mediated regulation of PQM-1 expression in neurons impacts gene expression throughout C. elegans and regulates survival from hypoxia.PLoS biology · 2023Article
- Distinct neuropeptide-receptor modules regulate a sex-specific behavioral response to a pheromone.Communications biology · 2021Article
- Pheromones Modulate Learning by Regulating the Balanced Signals of Two Insulin-like Peptides.Neuron · 2019Article
- A Pipeline for Volume Electron Microscopy of theFrontiers in neural circuits · 2018Article
- Myrf ER-Bound Transcription Factors Drive C. elegans Synaptic Plasticity via Cleavage-Dependent Nuclear Translocation.Developmental cell · 2017Article
- Divergent and convergent roles for insulin-like peptides in the worm, fly and mammalian nervous systems.Invertebrate neuroscience : IN · 2014Review
- The Nesprin family member ANC-1 regulates synapse formation and axon termination by functioning in a pathway with RPM-1 and β-Catenin.PLoS genetics · 2014Article
- A Caenorhabditis elegans developmental decision requires insulin signaling-mediated neuron-intestine communication.Development (Cambridge, England) · 2014Article
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- Oxygen sensing neurons and neuropeptides regulate survival after anoxia in developing C. elegans.PloS one · 2014Article
- The ubiquitin proteasome system in Caenorhabditis elegans and its regulation.Redox biology · 2014Review
- Neuropeptide signaling remodels chemosensory circuit composition in Caenorhabditis elegans.Nature neuroscience · 2013Article
- A Receptor Tyrosine Kinase Plays Separate Roles in Sensory Integration and Associative Learning ineNeuroArticle
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
Abstract
A neuronal F-box protein FSN-1 regulates Caenorhabditis elegans neuromuscular junction development by negatively regulating DLK-mediated MAPK signalling. In the present study, we show that attenuation of insulin/IGF signalling also contributes to FSN-1-dependent synaptic development and function. The aberrant synapse morphology and synaptic transmission in fsn-1 mutants are partially and specifically rescued by reducing insulin/IGF-signalling activity in postsynaptic muscles, as well as by reducing the activity of EGL-3, a prohormone convertase that processes agonistic insulin/IGF ligands INS-4 and INS-6, in neurons. FSN-1 interacts with, and potentiates the ubiquitination of EGL-3 in vitro, and reduces the EGL-3 level in vivo. We propose that FSN-1 may negatively regulate insulin/IGF signalling, in part, through EGL-3-dependent insulin-like ligand processing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.