ArticleInternational journal of molecular sciences2013
A novel colorimetric immunoassay utilizing the peroxidase mimicking activity of magnetic nanoparticles.
Article in International journal of molecular sciences, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 70 citations in OpenAlex.
- Green Synthesis of Biocompatible Gold Nanoparticles UsingACS organic & inorganic Au · 2025Article
- Electrostatically driven fluorescent sensor for rapid detection of AChE activity and organophosphate pesticides via dual-enzyme cascade amplification.Frontiers in pharmacology · 2025Article
- Article
- Magnetic iron oxide-based nanozymes: from synthesis to application.Nanoscale advances · 2024Review
- Antibody-Conjugated Magnetic Nanoparticle Therapy for Inhibiting T-Cell Mediated Inflammation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Effects of Iron Oxide Nanoparticle Supplementation on the Growth Performance, Serum Metabolites, Meat Quality, and Jejunal Basal Morphology in Broilers.Animals : an open access journal from MDPI · 2023Article
- Exploiting the Potential of Magnetic Nanoparticles for Rapid Diagnosis Tests (RDTs): Nanoparticle-Antibody Conjugates and Color Development Strategies.Diagnostics (Basel, Switzerland) · 2023Article
- Recent Advances in Colorimetric Tests for the Detection of Infectious Diseases and Antimicrobial Resistance.Diagnostics (Basel, Switzerland) · 2023Review
- Biosynthesis and applications of iron oxide nanocomposites synthesized by recombinant Escherichia coli.Applied microbiology and biotechnology · 2022Article
- Recent Advances in Aptasensors For Rapid and Sensitive Detection ofFrontiers in bioengineering and biotechnology · 2022Review
- Detection of white spot syndrome virus in seafood samples using a magnetosome-based impedimetric biosensor.Archives of virology · 2021Article
- Multienzymes activity of metals and metal oxide nanomaterials: applications from biotechnology to medicine and environmental engineering.Journal of nanobiotechnology · 2021Review
- Progress in the Application of Carbon Dots-Based Nanozymes.Frontiers in chemistry · 2021Review
- Development of magnetosomes-based biosensor for the detection ofIET nanobiotechnology · 2020Article
- Progress of Iron-Based Nanozymes for Antitumor Therapy.Frontiers in chemistry · 2020Review
- Inorganic Complexes and Metal-Based Nanomaterials for Infectious Disease Diagnostics.Chemical reviews · 2019Review
- Biocompatible zwitterionic copolymer-stabilized magnetite nanoparticles: a simple one-pot synthesis, antifouling properties and biomagnetic separation.RSC advances · 2018Article
- Exploration of Nanoparticle-Mediated Photothermal Effect of TMB-HAnalytical chemistry · 2018Article
- Recent Trends in Nanomaterials-Based Colorimetric Detection of Pathogenic Bacteria and Viruses.Small methods · 2018Review
- Synergistic Degradation of a Hyperuricemia-Causing Metabolite Using One-Pot Enzyme-Nanozyme Cascade Reactions.Scientific reports · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A simple colorimetric immunoassay system, based on the peroxidase mimicking activity of Fe3O4 magnetic nanoparticles (MNPs), has been developed to detect clinically important antigenic molecules. MNPs with ca. 10 nm in diameter were synthesized and conjugated with specific antibodies against target molecules, such as rotaviruses and breast cancer cells. Conjugation of the MNPs with antibodies (MNP-Abs) enabled specific recognition of the corresponding target antigenic molecules through the generation of color signals arising from the colorimetric reaction between the selected peroxidase substrate, 3,3',5,5'-tetramethylbenzidine (TMB) and H2O2. Based on the MNP-promoted colorimetric reaction, the target molecules were detected and quantified by measuring absorbance intensities corresponding to the oxidized form of TMB. Owing to the higher stabilities and economic feasibilities of MNPs as compared to horseradish peroxidase (HRP), the new colorimetric system employing MNP-Abs has the potential of serving as a potent immunoassay that should substitute for conventional HRP-based immunoassays. The strategy employed to develop the new methodology has the potential of being extended to the construction of simple diagnostic systems for a variety of biomolecules related to human cancers and infectious diseases, particularly in the realm of point-of-care applications.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.