ArticleG3 (Bethesda, Md.)2013
The rate and effects of spontaneous mutation on fitness traits in the social amoeba, Dictyostelium discoideum.
Article in G3 (Bethesda, Md.), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
12 citing papers in PubMed, 20 citations in OpenAlex.
- Spontaneous single-nucleotide substitutions and microsatellite mutations have distinct distributions of fitness effects.PLoS biology · 2024Article
- Very Low Rates of Spontaneous Gene Deletions and Gene Duplications in Dictyostelium discoideum.Journal of molecular evolution · 2023Article
- Selection in a growing colony biases results of mutation accumulation experiments.Scientific reports · 2022Article
- Context dependence in the symbiosis betweenEvolution letters · 2022Article
- Fitness effects of spontaneous mutations in a warming world.Evolution; international journal of organic evolution · 2021Article
- Low Base-Substitution Mutation Rate but High Rate of Slippage Mutations in the Sequence Repeat-Rich Genome ofG3 (Bethesda, Md.) · 2020Article
- Old Trade, New Tricks: Insights into the Spontaneous Mutation Process from the Partnering of Classical Mutation Accumulation Experiments with High-Throughput Genomic Approaches.Genome biology and evolution · 2019Review
- Genetic signatures of microbial altruism and cheating in social amoebas in the wild.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Spontaneous Mutation Rate in the Smallest Photosynthetic Eukaryotes.Molecular biology and evolution · 2017Article
- Genetic drift, selection and the evolution of the mutation rate.Nature reviews. Genetics · 2016Review
- Fitness Effects of Spontaneous Mutations in Picoeukaryotic Marine Green Algae.G3 (Bethesda, Md.) · 2016Article
- Gene Expression Evolves under a House-of-Cards Model of Stabilizing Selection.Molecular biology and evolution · 2015Article
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Authors and funding
5 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We performed a mutation accumulation (MA) experiment in the social amoeba Dictyostelium discoideum to estimate the rate and distribution of effects of spontaneous mutations affecting eight putative fitness traits. We found that the per-generation mutation rate for most fitness components is 0.0019 mutations per haploid genome per generation or larger. This rate is an order of magnitude higher than estimates for fitness components in the unicellular eukaryote Saccharomyces cerevisiae, even though the base-pair substitution rate is two orders of magnitude lower. The high rate of fitness-altering mutations observed in this species may be partially explained by a large mutational target relative to S. cerevisiae. Fitness-altering mutations also may occur primarily at simple sequence repeats, which are common throughout the genome, including in coding regions, and may represent a target that is particularly likely to give fitness effects upon mutation. The majority of mutations had deleterious effects on fitness, but there was evidence for a substantial fraction, up to 40%, being beneficial for some of the putative fitness traits. Competitive ability within the multicellular slug appears to be under weak directional selection, perhaps reflecting the fact that slugs are sometimes, but not often, comprised of multiple clones in nature. Evidence for pleiotropy among fitness components across MA lines was absent, suggesting that mutations tend to act on single fitness components.
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