Evidence map›Paper›PMID 23665540›Full record

ArticleTranscription

Decoding human gene expression signatures in the brain.

Guang-Zhong Wang, Genevieve Konopka

Abstract read
In one paragraph

Article in Transcription. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Guang-Zhong WangDepartment of Neuroscience; UT Southwestern Medical Center; Dallas, TX USA.
Genevieve Konopka

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The evolution of higher cognitive functions in humans is thought to be due, at least in part, to the molecular evolution of gene expression patterns specific to the human brain. In this article, we explore recent and past findings using comparative genomics in human and non-human primate brain to identify these novel human patterns. We suggest additional directions and lines of experimentation that should be taken to improve our understanding of these changes on the human lineage. Finally, we attempt to put into context these genomic changes with biological phenotypes and diseases in humans.

Indexed as

TranscriptomeAnimalsBrainELAV-Like Protein 2ELAV ProteinsHumansMicroRNAsPrimatesRNARNA SplicingTranscription FactorsELAVL2 protein, humanELAV-Like Protein 2ELAV ProteinsMicroRNAsRNATranscription Factorsbraincoexpressionevolutiongene expressiongenomicsnervous system

Identifiers

PMID23665540
PMCPMC4042582

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.