ReviewEuropean journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V2013
Application of in vitro biopharmaceutical methods in development of immediate release oral dosage forms intended for paediatric patients.
Review in European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed.
- VitroBert: modeling DILI by pretraining BERT on in vitro data.Journal of cheminformatics · 2025Article
- State of the art in pediatric nanomedicines.Drug delivery and translational research · 2024Review
- Article
- Crushing lopinavir/ritonavir tablets does not result in lower exposure to lopinavir/ritonavir in adult patients with COVID-19.European journal of hospital pharmacy : science and practice · 2023Article
- Performance Evaluation of Montelukast Pediatric Formulations: Part I-Age-Related In Vitro Conditions.The AAPS journal · 2022Article
- Performance Evaluation of Montelukast Pediatric Formulations: Part II - a PBPK Modelling Approach.The AAPS journal · 2022Article
- Article
- Classification of WHO Essential Oral Medicines for Children Applying a Provisional Pediatric Biopharmaceutics Classification System.Pharmaceutics · 2019Article
- Combined Approach of Cyclodextrin Complexationand Nanostructured Lipid Carriers for the Development of a Pediatric Liquid Oral Dosage Form of Hydrochlorothiazide.Pharmaceutics · 2018Article
- Article
- Investigating Oral Absorption of Carbamazepine in Pediatric Populations.The AAPS journal · 2017Article
- UnderstandingActa pharmaceutica Sinica. B · 2017Review
- Safe and effective pharmacotherapy in infants and preschool children: importance of formulation aspects.Archives of disease in childhood · 2016Review
- Using Physiologically Based Pharmacokinetic (PBPK) Modelling to Gain Insights into the Effect of Physiological Factors on Oral Absorption in Paediatric Populations.The AAPS journal · 2016Article
- Pediatric Biopharmaceutical Classification System: Using Age-Appropriate Initial Gastric Volume.The AAPS journal · 2016Article
- Development of oral dispersible tablets containing prednisolone nanoparticles for the management of pediatric asthma.Drug design, development and therapy · 2015Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Biopharmaceutics is routinely used in the design and development of medicines to generate science based evidence to predict in vivo performance; the application of this knowledge specifically to paediatric medicines development is yet to be explored. The aim of this review is to present the current status of available biopharmaceutical tools and tests including solubility, permeability and dissolution that may be appropriate for use in the development of immediate release oral paediatric medicines. The existing tools used in adults are discussed together with any limitations for their use within paediatric populations. The results of this review highlight several knowledge gaps in current methodologies in paediatric biopharmaceutics. The authors provide recommendations based on existing knowledge to adapt tests to better represent paediatric patient populations and also provide suggestions for future research that may lead to better tools to evaluate paediatric medicines.
Indexed as
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.