Evidence map›Paper›PMID 23665370›Full record

Trial reportJournal of the American College of Cardiology2013

Effect of endurance exercise training on endothelial function and arterial stiffness in older patients with heart failure and preserved ejection fraction: a randomized, controlled, single-blind trial.

Dalane W Kitzman, Peter H Brubaker, David M Herrington, Timothy M Morgan, Kathryn P Stewart, W Gregory Hundley, Abdelhamed Abdelhamed, Mark J Haykowsky

3 registry-linked trialsOpen access · greenAbstract readComparative StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of the American College of Cardiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 181 papers, 28 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
181citing papers in PubMed, 28 pooled it
19.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01113840 nacompletednot on this map

Exercise Conditioning in Elderly Patients With Heart Failure

TypeinterventionalSponsorWake Forest UniversityRan1993 to 2009Enrolled201ConditionsHeart FailureArmsExercise, Control
NCT04425785 nacompletednot on this mapstarted 2019, after this paper: background citation

Physical Exercise and Mental Wellbeing Rehabilitation for Acute Stress-induced Takotsubo Cardiomyopathy: The PLEASE Study

TypeinterventionalSponsorUniversity of AberdeenRan2019 to 2023Enrolled76ConditionsTakotsubo CardiomyopathyArmsPhysical Exercise Program, Cognitive Behavioural Therapy
NCT04467411 active not recruitingnot on this mapstarted 2020, after this paper: background citation

Randomised Controlled Study of Physical Exercise Intervention in Breast Cancer Patients at Risk of Anthracycline-induced Cardiomyopathy:The EMBRACE Study

TypeobservationalSponsorUniversity of AberdeenRan2020 to 2030Enrolled70ConditionsBreast Cancer
3 · Its place in the literature

Who cites it

181 citing papers in PubMed, 28 syntheses or guidelines pooled it, 354 citations in OpenAlex.

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  17. Exercise Intensity in Patients with Cardiovascular Diseases: Systematic Review with Meta-Analysis.International journal of environmental research and public health · 2021
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121 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Dalane W KitzmanCardiology Section, Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina 27157-1045, USA. dkitzman@wfubmc.edu
Peter H Brubaker
David M Herrington
Timothy M Morgan
Kathryn P Stewart
W Gregory Hundley
Abdelhamed Abdelhamed
Mark J Haykowsky
Wake Forest University · USGood Samaritan Hospital · USUniversity of Alberta · CA

Funding

Wake Forest Claude D. Pepper OAIC - RenewalP30AG021332 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Jamie Nicole Justice · 2002 to 2026
$36.4M
WORKER PROTECTION AGAINST AIRBORNE INFLUENZA - A PILOT STUDYM01RR007122 · NCRR · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI HUNDLEY, WILLIAM GREGORY · 1992 to 2010
$35.2M
Exercise Intolerance in Older HFPEF PatientsR01AG018915 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI KITZMAN, DALANE W · 2001 to 2019
$5.2M
Exercise Intolerance in Elderly Diastolic Heart FailureR37AG018915 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI KITZMAN, DALANE W · 2005 to 2013
$3.4M
EXERCISE TRAINING EFFECT ON DIASTOLIC DYSFUNCTIONR01AG012257 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI KITZMAN, DALANE W · 1994 to 2000
$318k
NCRR NIH HHS M01 RR007122NIA NIH HHS P30 AG021332NIA NIH HHS P30AG021332NIA NIH HHS R01 AG018915NIA NIH HHS R01AG12257NIA NIH HHS R37 AG018915NIA NIH HHS R37AG18915
6 · The paper itself

Abstract

objectivesThe study sought to evaluate the effects of endurance exercise training (ET) on endothelial-dependent flow-mediated arterial dilation (FMD) and carotid artery stiffness, and their potential contributions to the training-related increase in peak exercise oxygen consumption (Vo2) in older patients with heart failure with preserved ejection fraction (HFPEF).

backgroundElderly HFPEF patients have severely reduced peak Vo2, which improves with ET, however, the mechanisms of this improvement are unclear. FMD and arterial distensibility are critical components of the exercise response and are reduced with aging. However, it is unknown whether these improve with ET in elderly HFPEF or contribute to the training-related improvement in peak Vo2.

methodsA total of 63 HFPEF patients (age 70 ± 7 years) were randomized to 16 weeks of ET (walking, arm and leg ergometry, n = 32) or attention control (CT) (n = 31). Peak Vo2, brachial artery FMD in response to cuff ischemia, carotid artery distensibility by high-resolution ultrasound, left ventricular function, and quality of life were measured at baseline and follow-up.

resultsET increased peak Vo2 (ET: 15.8 ± 3.3 ml/kg/min vs. CT: 13.8 ± 3.1 ml/kg/min, p = 0.0001) and quality of life. However, brachial artery FMD (ET: 3.8 ± 3.0% vs. CT: 4.3 ± 3.5%, p = 0.88), and carotid arterial distensibility (ET: 0.97 ± 0.56 vs. CT: 1.07 ± 0.34 × 10(-3) mm·mm Hg(-2); p = 0.65) were unchanged. Resting left ventricular systolic and diastolic function were unchanged by ET.

conclusionsIn elderly HFPEF patients, 16 weeks of ET improved peak Vo2 without altering endothelial function or arterial stiffness. This suggests that other mechanisms, such as enhanced skeletal muscle perfusion and/or oxygen utilization, may be responsible for the ET-mediated increase in peak Vo2 in older HFPEF patients. (Prospective Aerobic Reconditioning Intervention Study [PARIS]; NCT01113840).

Indexed as

AgedAged, 80 and overAge FactorsAngiographyCarotid ArteriesEndothelium, VascularExercise TherapyExercise ToleranceFemaleFollow-Up StudiesHeart FailureHumansMaleOxygen ConsumptionProspective StudiesQuality of Lifeagingarteriovenous oxygen differenceattention controlA-Vo(2)DiffBNPB-type natriuretic peptideCTETexerciseexercise trainingflow-mediated arterial dilationFMDheart failureheart failure with preserved ejection fractionheart failure with reduced ejection fractionHFHFPEFHFREFleft ventricularLVoxygen consumptionpeak exercise oxygen uptakepreserved ejection fractionQOLquality of lifeRERrespiratory exchange ratioVo(2)Vo(2)peak

Identifiers

PMID23665370
PMCPMC3740089
OpenAlexW113644040

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.