ArticleRespiratory physiology & neurobiology2013
Circadian dependence of receptors that mediate wake-related excitatory drive to hypoglossal motoneurons.
Article in Respiratory physiology & neurobiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 18 citations in OpenAlex.
- Variations in loop gain and arousal threshold during NREM sleep are affected by time of day over a 24-hour period in participants with obstructive sleep apnea.Journal of applied physiology (Bethesda, Md. : 1985) · 2020Article
- Circadian clock genes and respiratory neuroplasticity genes oscillate in the phrenic motor system.American journal of physiology. Regulatory, integrative and comparative physiology · 2020Article
- Increased tongue use enhances 5-HTRespiratory physiology & neurobiology · 2019Article
- Single neuron serotonin receptor subtype gene expression correlates with behaviour within and across three molluscan species.Proceedings. Biological sciences · 2018Article
- Hypoglossal motoneurons are endogenously activated by serotonin during the active period of circadian cycle.Respiratory physiology & neurobiology · 2018Article
- Neural Control of the Upper Airway: Respiratory and State-Dependent Mechanisms.Comprehensive Physiology · 2016Review
- Sleep-wake control of the upper airway by noradrenergic neurons, with and without intermittent hypoxia.Progress in brain research · 2014Article
- Sleep and breathing. Foreword.Respiratory physiology & neurobiology · 2013Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Serotonin (5-HT), norepinephrine and orexins (ORX) are the three best established mediators of wake-related activation of hypoglossal (XII) motoneurons that innervate the muscles of the tongue. Since the tongue's use is temporarily closely aligned with the rest-activity cycle, we tested whether expression of mRNA for relevant 5-HT, norepinephrine and ORX receptors varies in the XII nucleus with the rest-activity cycle. Adult rats (n=7-9/group) were decapitated at 8-9 am (near rest period onset) or at 6-7 pm (near active period onset). Tissue micropunches were extracted from medullary slices containing the XII motor and sensory external cuneate (ECN) nuclei. 5-HT2A, α1-adrenergic and ORX type 2 receptor mRNAs were quantified using RT-PCR. Only 5-HT2A receptor mRNA levels differed between the two time points and were higher at the active period onset; no differences were detected in the ECN. Consistent with the mRNA results, 5-HT2A protein levels were also higher in the XII nucleus at the active period onset than at rest onset. Thus, the endogenous serotonergic excitatory drive to XII motoneurons may be enhanced through circadian- or activity-dependent mechanisms that increase the availability of 5-HT2A receptors prior to the active period. Conversely, reduced levels of 5-HT2A receptors during the rest-sleep period may exacerbate the propensity for sleep-disordered breathing in subjects with anatomically compromised upper airway.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.