ArticleBiochemical and biophysical research communications2013
The SNAI1 and SNAI2 proteins occupy their own and each other's promoter during chondrogenesis.
Article in Biochemical and biophysical research communications, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 21 citations in OpenAlex.
- Epithelial-to-mesenchymal transition transcription factors: New strategies for mesenchymal tissue regeneration.Cytokine & growth factor reviews · 2025Review
- Heterogeneity and plasticity of epithelial-mesenchymal transition (EMT) in cancer metastasis: Focusing on partial EMT and regulatory mechanisms.Cell proliferation · 2023Review
- Regulation of Partial and Reversible Endothelial-to-Mesenchymal Transition in Angiogenesis.Frontiers in cell and developmental biology · 2021Article
- Genetics Underlying the Interactions between Neural Crest Cells and Eye Development.Journal of developmental biology · 2020Review
- A Computational Model of the Endothelial to Mesenchymal Transition.Frontiers in genetics · 2020Article
- Molecular regulation of Snai2 in development and disease.Journal of cell science · 2019Review
- SNAI1 recruits HDAC1 to suppress SNAI2 transcription during epithelial to mesenchymal transition.Scientific reports · 2019Article
- Snail/Slug-YAP/TAZ complexes cooperatively regulate mesenchymal stem cell function and bone formation.Cell cycle (Georgetown, Tex.) · 2017Article
- Snail/Slug binding interactions with YAP/TAZ control skeletal stem cell self-renewal and differentiation.Nature cell biology · 2016Article
- 14-3-3σ Gene Loss Leads to Activation of the Epithelial to Mesenchymal Transition Due to the Stabilization of c-Jun Protein.The Journal of biological chemistry · 2016Article
- Article
- Fatal autoimmunity results from the conditional deletion of Snai2 and Snai3.Cellular immunology · 2015Article
- Snail transcription factors in hematopoietic cell development: a model of functional redundancy.Experimental hematology · 2014Review
- Snail1-dependent control of embryonic stem cell pluripotency and lineage commitment.Nature communications · 2014Article
- Absence of a major role for the snai1 and snai3 genes in regulating skeletal muscle regeneration in mice.PLoS currents · 2013Article
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Two Snail family genes, Snai1 and Snai2, encode E2 box-binding transcriptional repressors that are important for cartilage development during long bone formation in mice. We demonstrated previously that the Snai1 and Snai2 genes function redundantly, and compensate for each other's loss during mouse chondrogenesis in vivo. A prediction from this genetic data is that the SNAI1 and SNAI2 proteins can bind to each other's promoter to regulate gene expression. Here we demonstrate that expression of Snai1 and Snai2 RNA and protein is induced during chondrogenic differentiation of cultured mouse ATDC5 cells. Using chromatin immunoprecipitation assays, we then show that endogenous SNAI1 and SNAI2 proteins bind to a subset of E2 boxes in both their own and each other's promoter in differentiating ATDC5 cells. Together with our previous genetic data, these results support the model that expression of the Snai1 and Snai2 genes is negatively regulated by their protein products occupying each other's promoter during chondrogenesis, and help provide an explanation for the genetic redundancy observed in the mouse loss of function models.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.