ReviewExperimental cell research2013
Fibroblast morphogenesis on 3D collagen matrices: the balance between cell clustering and cell migration.
Review in Experimental cell research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 49 citations in OpenAlex.
- Synthetic Surrogates of Collagen-Rich Microenvironments: Integrating Modular Bioactive Fibrillar Structure and Tunable Viscoelasticity via Multifunctional Assembling Peptides.ACS central science · 2026Article
- Novel high throughput 3D ECM remodeling assay identifies MEK as key driver of fibrotic fibroblast activity.Materials today. Bio · 2025Article
- 3D-cell phantom-experimental setup to assess thermal effects and cell viability of lung tumor cells after electroporation.Scientific reports · 2024Article
- FOXO1 regulates wound-healing responses in human gingival fibroblasts.Journal of periodontal research · 2024Article
- Collective Cell Radial Ordered Migration in Spatial Confinement.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Microstructured click hydrogels for cell contact guidance in 3D.Materials today. Bio · 2023Article
- Generation and Characterization of a Tumor Stromal Microenvironment and Analysis of Its Interplay with Breast Cancer Cells: An In Vitro Model to Study Breast Cancer-Associated Fibroblast Inactivation.International journal of molecular sciences · 2022Article
- Enhanced wound healing via collagen-turnover-driven transfer of PDGF-BB gene in a murine wound model.ACS applied bio materials · 2020Article
- Mechanophenotyping of 3D multicellular clusters using displacement arrays of rendered tractions.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Regulation of opticin on bioactivity of retinal vascular endothelial cells cultured in collagen.International journal of ophthalmology · 2020Article
- Heterogeneous nuclear ribonucleoprotein A2/B1 is a negative regulator of human breast cancer metastasis by maintaining the balance of multiple genes and pathways.EBioMedicine · 2020Article
- Article
- Hair follicle dermal condensation forms via Fgf20 primed cell cycle exit, cell motility, and aggregation.eLife · 2018Article
- Emergent cellular self-organization and mechanosensation initiate follicle pattern in the avian skin.Science (New York, N.Y.) · 2017Article
- Hair Germ Model In Vitro via Human Postnatal Keratinocyte-Dermal Papilla Interactions: Impact of Hyaluronic Acid.Stem cells international · 2017Article
- Generation and analysis of spheroids from human primary skin myofibroblasts: an experimental system to study myofibroblasts deactivation.Cell death discovery · 2017Article
- Article
- Novel insights into the function and dynamics of extracellular matrix in liver fibrosis.American journal of physiology. Gastrointestinal and liver physiology · 2015Review
- PDGF‑stimulated dispersal of cell clusters and disruption of fibronectin matrix on three-dimensional collagen matrices requires matrix metalloproteinase-2.Molecular biology of the cell · 2015Article
- Collagen matrix as a tool in studying fibroblastic cell behavior.Cell adhesion & migration · 2015Review
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Fibroblast clusters have been observed in tissues under a variety of circumstances: in fibrosis and scar, in the formation of hair follicle dermal papilla, and as part of the general process of mesenchymal condensation that takes place during development. Cell clustering has been shown to depend on features of the extracellular matrix, growth factor environment, and mechanisms to stabilize cell-cell interactions. In vitro studies have shown that increasing the potential for cell-cell adhesion relative to cell-substrate adhesion promotes cell clustering. Experimental models to study fibroblast clustering have utilized centrifugation, hanging drops, and substrata with poorly adhesive, soft and mechanically unstable properties. In this review, we summarize work on a new, highly tractable, cell clustering research model in which human fibroblasts are incubated on the surfaces of collagen matrices. Fibroblast clustering occurs under procontractile growth factor conditions (e.g., serum or the serum lipid agonist lysophosphatidic acid) but not under promigratory growth factor conditions (e.g., platelet-derived growth factor) and can be reversed by switching growth factor environments. Cell contraction plays a dual role in clustering to bring cells closer together and to stimulate cells to organize fibronectin into a fibrillar matrix. Binding of fibroblasts to a shared fibronectin fibrillar matrix stabilizes clusters, and fragmentation of the fibrillar matrix occurs when growth factor conditions are switched to promote cell dispersal.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.