Evidence map›Paper›PMID 23664834›Full record

ReviewExperimental cell research2013

Cell and tissue mechanics in cell migration.

Janina R Lange, Ben Fabry

Abstract readReview
In one paragraph

Review in Experimental cell research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 82 papers.

0numbers the graph read from it
0cells of the map it votes in
82citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

82 citing papers in PubMed.

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  17. Mechanisms Underlying the Rarity of Skeletal Muscle Cancers.International journal of molecular sciences · 2024
    Review
  18. Article
  19. Article
  20. Article

22 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Janina R LangeDepartment of Physics, University of Erlangen-Nuremberg, Erlangen 91052, Germany.
Ben Fabry

Funding

Micromechanics of the airway smooth muscle cellR01HL065960 · NHLBI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI FREDBERG, JEFFREY J · 2000 to 2009
$6.3M
NHLBI NIH HHS HL65960NHLBI NIH HHS R01 HL065960
6 · The paper itself

Abstract

Migrating cells generate traction forces to counteract the movement-resisting forces arising from cell-internal stresses and matrix adhesions. In the case of collective migration in a cell colony, or in the case of 3-dimensional migration through connective tissue, movement-resisting forces arise also from external stresses. Although the deformation of a stiffer cell or matrix causes larger movement-resisting forces, at the same time a larger stiffness can also promote cell migration due to a feedback between forces, deformations, and deformation speed that is mediated by the acto-myosin contractile machinery of cells. This mechanical feedback is also important for stiffness sensing, durotaxis, plithotaxis, and collective migration in cell colonies.

Indexed as

AnimalsCell AdhesionCell MovementFeedbackHumansMechanotransduction, CellularMuscle CellsMuscle ContractionMyosinsStress, MechanicalMyosinsActo-myosin interactionCell mechanicsCell migrationHill-curveMechanotransductionTissue mechanics

Identifiers

PMID23664834
PMCPMC3773016

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.