Evidence map›Paper›PMID 23664631›Full record

ArticleThe Journal of pediatrics2013

Disorders of protein misfolding: alpha-1-antitrypsin deficiency as prototype.

Gary A Silverman, Stephen C Pak, David H Perlmutter

Abstract read
In one paragraph

Article in The Journal of pediatrics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. Review
  9. The Intersection of Aging Biology and the Pathobiology of Lung Diseases: A Joint NHLBI/NIA Workshop.The journals of gerontology. Series A, Biological sciences and medical sciences · 2017
    Review
  10. Review
  11. Review
  12. Article
  13. Article
  14. C. elegans in high-throughput drug discovery.Advanced drug delivery reviews · 2014
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Gary A SilvermanDepartment of Pediatrics, University of Pittsburgh School of Medicine, Children's Hospital of Pittsburgh and Magee Women's Hospital of University of Pittsburgh Medical Center, Pittsburgh, PA 15224, USA.
Stephen C Pak
David H Perlmutter

Funding

Treating AT Deficiency with Drugs that Modulate the Proteostasis NetworkP01DK096990 · NIDDK · WASHINGTON UNIVERSITY · PI SILVERMAN, GARY ARTHUR · 2012 to 2023
$18.3M
High Throughput Genetic and Drug Screens for Alph-1-Antitrypsin DeficiencyR01DK079806 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SILVERMAN, GARY ARTHUR · 2008 to 2011
$2.4M
Hepatocellular Carcinoma in Antitrypsin DeficiencyR01DK076918 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI PERLMUTTER, DAVID H · 2008 to 2012
$2.1M
Novel Pharmacological Strategies for Liver Disease in Antitrypsin DeficiencyR01DK084512 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI PERLMUTTER, DAVID H · 2009 to 2012
$1.6M
NIDDK NIH HHS P01 DK096990NIDDK NIH HHS P01DK096990NIDDK NIH HHS R01 DK076918NIDDK NIH HHS R01DK076918NIDDK NIH HHS R01 DK079806NIDDK NIH HHS R01DK079806NIDDK NIH HHS R01 DK084512NIDDK NIH HHS R01DK084512
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

alpha 1-Antitrypsin DeficiencyProteostasis DeficienciesAnimalsCaenorhabditis elegansDisease Models, AnimalHumansAlpha-1-antitrypsinAlpha-1-antitrypsin deficiencyATATDATMATZCarbamazepineCBZChronic obstructive pulmonary diseaseCOPDEndoplasmic reticulumERFDAFederal Drug AdministrationMutant alpha-1-antitrypsin ZNormal (wild type) alpha-1-antitrypsinPBAPhenylbutyric acidRNAiRNA interferenceSingle nucleotide polymorphismSNP

Identifiers

PMID23664631
PMCPMC3725216

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.