ArticleCurrent biology : CB2013
Bacterial discrimination by dictyostelid amoebae reveals the complexity of ancient interspecies interactions.
Article in Current biology : CB, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed.
- Chemotaxis and selective interactions ofbioRxiv : the preprint server for biology · 2026Article
- The Use of Free-Living Amoeba in Treating Bacterial Infections: Thermotolerant Dictyostelids Are Avirulent and Do Not Cause Keratitis in Mice.Investigative ophthalmology & visual science · 2026Article
- Symbiotic T6SS affects horizontal transmission ofISME communications · 2025Article
- Costs of being a diet generalist for the protist predatorProceedings of the National Academy of Sciences of the United States of America · 2024Article
- Bacterial capsules: Occurrence, mechanism, and function.NPJ biofilms and microbiomes · 2024Review
- Adaptation to novel spatially-structured environments is driven by the capsule and alters virulence-associated traits.Nature communications · 2022Article
- Neutrophils and aquatic pathogens.Parasite immunology · 2022Review
- The genetic architecture underlying prey-dependent performance in a microbial predator.Nature communications · 2022Article
- Mutant resources for functional genomics in Dictyostelium discoideum using REMI-seq technology.BMC biology · 2021Article
- Inferring Adaptive Codon Preference to Understand Sources of Selection Shaping Codon Usage Bias.Molecular biology and evolution · 2021Article
- Article
- The Ecology and Evolution of Amoeba-Bacterium Interactions.Applied and environmental microbiology · 2021Review
- Bacteriomic Profiling of Branchial Lesions Induced byMicroorganisms · 2020Article
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- Transcriptional Responses ofFrontiers in microbiology · 2020Article
- LrrkA, a kinase with leucine-rich repeats, links folate sensing with Kil2 activity and intracellular killing.Cellular microbiology · 2020Article
- Intracellular Burkholderia Symbionts induce extracellular secondary infections; driving diverse host outcomes that vary by genotype and environment.The ISME journal · 2019Article
- Conditional expression explains molecular evolution of social genes in a microbe.Nature communications · 2019Article
- Social amoebae establish a protective interface with their bacterial associates by lectin agglutination.Science advances · 2019Article
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Abstract
backgroundAmoebae and bacteria interact within predator-prey and host-pathogen relationships, but the general response of amoeba to bacteria is not well understood. The amoeba Dictyostelium discoideum feeds on, and is colonized by, diverse bacterial species, including Gram-positive [Gram(+)] and Gram-negative [Gram(-)] bacteria, two major groups of bacteria that differ in structure and macromolecular composition.
resultsTranscriptional profiling of D. discoideum revealed sets of genes whose expression is enriched in amoebae interacting with different species of bacteria, including sets that appear specific to amoebae interacting with Gram(+) or with Gram(-) bacteria. In a genetic screen utilizing the growth of mutant amoebae on a variety of bacteria as a phenotypic readout, we identified amoebal genes that are only required for growth on Gram(+) bacteria, including one that encodes the cell-surface protein gp130, as well as several genes that are only required for growth on Gram(-) bacteria, including one that encodes a putative lysozyme, AlyL. These genes are required for parts of the transcriptional response of wild-type amoebae, and this allowed their classification into potential response pathways.
conclusionsWe have defined genes that are critical for amoebal survival during feeding on Gram(+), or Gram(-), bacteria that we propose form part of a regulatory network that allows D. discoideum to elicit specific cellular responses to different species of bacteria in order to optimize survival.
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