SynthesisAtherosclerosis2013
The shared allelic architecture of adiponectin levels and coronary artery disease.
Synthesis in Atherosclerosis, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 37 citations in OpenAlex.
- Similarity and diversity of genetic architecture for complex traits between East Asian and European populations.BMC genomics · 2023Article
- Detecting associated genes for complex traits shared across East Asian and European populations under the framework of composite null hypothesis testing.Journal of translational medicine · 2022Article
- Causal associations of circulating adiponectin with cardiometabolic diseases and osteoporotic fracture.Scientific reports · 2022Article
- Effects of Adiponectin on T2DM and Glucose Homeostasis: A Mendelian Randomization Study.Diabetes, metabolic syndrome and obesity : targets and therapy · 2020Article
- Levels of nitric oxide metabolites, adiponectin and endothelin are associated with SNPs of the adiponectin and endothelin genes.Biomedical reports · 2019Article
- Metabolic Profiling of Adiponectin Levels in Adults: Mendelian Randomization Analysis.Circulation. Cardiovascular genetics · 2017Article
- Obesity-induced hypoadiponectinaemia: the opposite influences of central and peripheral fat compartments.International journal of epidemiology · 2017Article
- Mendelian Randomization Analysis Identifies CpG Sites as Putative Mediators for Genetic Influences on Cardiovascular Disease Risk.American journal of human genetics · 2017Article
- Review
- Role of Adiponectin in Coronary Heart Disease Risk: A Mendelian Randomization Study.Circulation research · 2016Article
- Genetics of non-conventional lipoprotein fractions.Current genetic medicine reports · 2015Article
- New and emerging biomarkers in cardiovascular disease.Current diabetes reports · 2015Review
- A Mendelian randomization study of the effect of type-2 diabetes on coronary heart disease.Nature communications · 2015Article
- Genome-wide studies of verbal declarative memory in nondemented older people: the Cohorts for Heart and Aging Research in Genomic Epidemiology consortium.Biological psychiatry · 2015Article
- No Evidence of a Causal Relationship between Plasma Homocysteine and Type 2 Diabetes: A Mendelian Randomization Study.Frontiers in cardiovascular medicine · 2015Article
- Novel metabolic biomarkers of cardiovascular disease.Nature reviews. Endocrinology · 2014Review
- Adiponectin gene polymorphisms and acute respiratory distress syndrome susceptibility and mortality.PloS one · 2014Article
Corrections and comments
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Authors and funding
9 authors at 7 institutions in 6 countries.
Funding
Abstract
objectiveA large body of epidemiologic data strongly suggests an association between excess adiposity and coronary artery disease (CAD). Low adiponectin levels, a hormone secreted only from adipocytes, have been associated with an increased risk of CAD in observational studies. However, these associations cannot clarify whether this relationship is causal or due to a shared set of causal factors or even confounding. Genome-wide association studies have identified common variants that influence adiponectin levels, providing valuable tools to examine the genetic relationship between adiponectin and CAD.
methodsUsing 145 genome wide significant SNPs for adiponectin from the ADIPOGen consortium (n = 49,891), we tested whether adiponectin-decreasing alleles influenced risk of CAD in the CARDIoGRAM consortium (n = 85,274).
resultsIn single-SNP analysis, 5 variants among 145 SNPs were associated with increased risk of CAD after correcting for multiple testing (P < 4.4 × 10(-4)). Using a multi-SNP genotypic risk score to test whether adiponectin levels and CAD have a shared genetic etiology, we found that adiponectin-decreasing alleles increased risk of CAD (P = 5.4 × 10(-7)).
conclusionThese findings demonstrate that adiponectin levels and CAD have a shared allelic architecture and provide rationale to undertake a Mendelian randomization studies to understand if this relationship is causal.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.