ReviewProgress in molecular biology and translational science2013
G protein-coupled receptor heterocomplexes in neuropsychiatric disorders.
Review in Progress in molecular biology and translational science, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 31 citations in OpenAlex.
- Dynamic monomer-dimer transition in ligand-induced apelin receptor activation.Nature communications · 2026Article
- The psychosis risk factorbioRxiv : the preprint server for biology · 2023Article
- Disruption of 5-hydroxytryptamine 1A receptor and orexin receptor 1 heterodimer formation affects novel G protein-dependent signaling pathways and has antidepressant effects in vivo.Translational psychiatry · 2022Article
- G Protein-Coupled Receptor Heteromers as Putative Pharmacotherapeutic Targets in Autism.Frontiers in cellular neuroscience · 2020Review
- GPCRM: a homology modeling web service with triple membrane-fitted quality assessment of GPCR models.Nucleic acids research · 2018Article
- Sorting nexin 3 mutation impairs development and neuronal function in Caenorhabditis elegans.Cellular and molecular life sciences : CMLS · 2018Article
- Ancestry-specific and sex-specific risk alleles identified in a genome-wide gene-by-alcohol dependence interaction study of risky sexual behaviors.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2017Article
- Genome-wide Analysis of RARβ Transcriptional Targets in Mouse Striatum Links Retinoic Acid Signaling with Huntington's Disease and Other Neurodegenerative Disorders.Molecular neurobiology · 2017Article
- Detection of Receptor Heteromerization Using In Situ Proximity Ligation Assay.Current protocols in pharmacology · 2016Article
- Molecular dynamics simulations and structure-based network analysis reveal structural and functional aspects of G-protein coupled receptor dimer interactions.Journal of computer-aided molecular design · 2016Article
- G Protein-Coupled Receptor Heteromers.Annual review of pharmacology and toxicology · 2016Review
- Deregulation of RGS17 Expression Promotes Breast Cancer Progression.Journal of Cancer · 2015Article
- G-protein-coupled receptor participates in 20-hydroxyecdysone signaling on the plasma membrane.Cell communication and signaling : CCS · 2014Article
- Optogenetics in preclinical neuroscience and psychiatry research: recent insights and potential applications.Neuropsychiatric disease and treatment · 2014Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
G protein-coupled receptors (or GPCRs) represent the largest family of membrane proteins in the human genome and are the target of approximately half of all therapeutic drugs. GPCRs contain a conserved structure of seven transmembrane domains. Their amino terminus is located extracellularly, whereas the carboxy terminus extends into the cytoplasm. Accumulating evidence suggests that GPCRs exist and function as monomeric entities. Nevertheless, more recent findings indicate that GPCRs can also form dimers or even higher order oligomers. The differential pharmacological and signaling properties of GPCR heteromeric complexes hint that their physiological effects may be different as compared to those obtained in tissue cultures that express a particular GPCR. In this chapter, we review current data on the role of GPCR heteromerization in receptor signaling, as well as its potential implication in neuropsychiatric disorders such as schizophrenia, depression, and Parkinson's disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.