ReviewProgress in molecular biology and translational science2013
Evolutionary, physicochemical, and functional mechanisms of protein homooligomerization.
Review in Progress in molecular biology and translational science, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- De novo design of light-responsive protein-protein interactions enables reversible formation of protein assemblies.Nature chemistry · 2025Article
- A somatic multiple myeloma mutation unravels a mechanism of oligomerization-mediated product inhibition in GGPPS.The FEBS journal · 2025Article
- DeepSub: Utilizing Deep Learning for Predicting the Number of Subunits in Homo-Oligomeric Protein Complexes.International journal of molecular sciences · 2024Article
- Article
- Variants of a putative baseplate wedge protein extend the host range of Pseudomonas phage K8.Microbiome · 2023Article
- A peptide interfering with the dimerization of oncogenic KITENIN protein and its stability suppresses colorectal tumour progression.Clinical and translational medicine · 2022Article
- Unraveling a Ligand-Induced Twist of a Homodimeric Enzyme by Pulsed Electron-Electron Double Resonance.Angewandte Chemie (International ed. in English) · 2021Article
- Contribution of the Oligomeric State to the Thermostability of Isoenzyme 3 fromMicroorganisms · 2018Article
- The Dimer-of-Trimers Assembly Prevents Catalysis at the Transferase Site of Prokaryotic FAD Synthase.Biophysical journal · 2018Article
- Structural and functional insights into the unique CBS-CP12 fusion protein family in cyanobacteria.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Ligand Binding Site Structure Influences the Evolution of Protein Complex Function and Topology.Cell reports · 2018Article
- Article
- Computational design of self-assembling cyclic protein homo-oligomers.Nature chemistry · 2017Article
- Life at the border: adaptation of proteins to anisotropic membrane environment.Protein science : a publication of the Protein Society · 2014Review
- Role of stoichiometry in the dimer-stabilizing effect of AMPA receptor allosteric modulators.ACS chemical biology · 2014Article
- Dimerization of PHGDH via the catalytic unit is essential for its enzymatic function.The Journal of biological chemistryArticle
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Protein homooligomers afford several important benefits for the cell; they mediate and regulate gene expression, activity of many enzymes, ion channels, receptors, and cell-cell adhesion processes. The evolutionary and physical mechanisms of oligomer formation are very diverse and are not well understood. Certain homooligomeric states may be conserved within protein subfamilies and between different subfamilies, therefore providing the specificity to particular substrates while minimizing interactions with unwanted partners. In addition, transitions between different oligomeric states may regulate protein activity and support the switch between different pathways. In this chapter, we summarize the biological importance of homooligomeric assemblies, physicochemical properties of their interfaces, experimental methods for their identification, their evolution, and role in human diseases.
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