ArticleJournal of cardiac failure2013
Medication adherence, depressive symptoms, and cardiac event-free survival in patients with heart failure.
Article in Journal of cardiac failure, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 3 of them syntheses that pooled it.
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Who cites it
26 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Influence of Social Determinants of Health on Heart Failure Outcomes: A Systematic Review.Journal of the American Heart Association · 2023Pooled it
- The Role of Depression on Treatment Adherence in Patients with Heart Failure-a Systematic Review of the Literature.Current cardiology reports · 2022Pooled it
- Prevalence and predictors of medication non-adherence among people living with multimorbidity: a systematic review and meta-analysis.BMJ open · 2021Pooled it
- Cognitive behavioral therapy for insomnia in stable heart failure: Protocol for a randomized controlled trial.Contemporary clinical trials · 2017Trial
- Cognitive assessment in heart failure: clinical value, timing, and practical tools.Heart failure reviews · 2026Review
- Assessment of Medication Adherence Among Heart Failure Patients in an Ambulatory Care Setting: A Prospective Observational Study.Journal of clinical medicine · 2026Article
- Psychosocial predictors of non-adherence to antihypertensive medication among Korean adults: A nationwide cross-sectional study.PloS one · 2026Article
- Return on Investment of Enhanced Behavioral Health Services.JAMA network open · 2025Article
- Evaluation of the AJournal of the American Heart Association · 2024Article
- Barriers to Medication Adherence Among Patients with Non-Communicable Disease in North Wollo Zone Public Hospitals: Socio-Ecologic Perspective, 2023.Patient preference and adherence · 2024Article
- Depression in Heart Failure with Reduced Ejection Fraction, an Undervalued Comorbidity: An Up-To-Date Review.Medicina (Kaunas, Lithuania) · 2023Review
- Assessment of medication adherence among Lebanese adult patients with non-communicable diseases during COVID-19 lockdown: a cross-sectional study.Frontiers in public health · 2023Article
- Risk of recurrent cardiovascular events in coronary artery disease patients with Type D personality.Frontiers in psychology · 2023Article
- Change in Depressive Symptoms During the First Month of Discharge and 1-Year Clinical Outcomes in Patients Hospitalized for Heart Failure.Journal of the American Heart Association · 2022Article
- Psychosocial characteristics of patients evaluated for kidney transplant and associations with functional and frailty metrics at a veterans affairs hospital.Clinical transplantation · 2022Article
- Effect of Medication and Dietary Compliance on Rehospitalization and the Quality of Life of Patients with Heart Failure.Florence Nightingale journal of nursing · 2020Article
- Physiological monitoring in the complex multimorbid heart failure patient - Conclusions.European heart journal supplements : journal of the European Society of Cardiology · 2019Article
- Prescription Drug Spending and Medication Adherence Among Medicare Beneficiaries with Heart Failure.Journal of managed care & specialty pharmacy · 2019Article
- The impact of medication nonadherence on the relationship between mortality risk and depression in heart failure.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2017Article
- Psychological stress and short-term hospitalisations or death in patients with heart failure.Heart (British Cardiac Society) · 2016Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
backgroundMedication nonadherence and depressive symptoms predict hospitalization and death in patients with heart failure (HF). Depressed patients have lower medication adherence than nondepressed patients. However, the predictive power of the combination of medication adherence and depressive symptoms for hospitalization and death has not been investigated in patients with HF.
objectiveThe aim of this study was to explore the combined influence of medication adherence and depressive symptoms for prediction of cardiac event-free survival in patients with HF. METHODS AND
resultsWe monitored medication adherence in 216 HF patients who completed the Patient Health Questionnaire-9 (PHQ-9) at baseline. Medication adherence was measured objectively with the use of the Medication Event Monitoring System (MEMS). Patients were followed for up to 3.5 years to collect data on cardiac events. Survival analyses were used to compare cardiac event-free survival among groups. The risk of experiencing a cardiac event for patients with medication nonadherence and depressive symptoms was 5 times higher than those who were medication adherent without depressive symptoms. The risk of experiencing a cardiac event for patients with only 1 risk factor was 1.2-1.3 times that of those with neither risk factor.
conclusionsMedication nonadherence and depressive symptoms had a negative synergistic effect on cardiac event-free survival in patients with HF.
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