ArticleBMC genetics2013
Genome-wide association study of antibody response to Newcastle disease virus in chicken.
Article in BMC genetics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 51 citations in OpenAlex.
- Genome-wide association study reveals putative genetic determinants of longitudinal immune responses to avian influenza and Newcastle disease in chickens.Genetics, selection, evolution : GSE · 2026Article
- Whole genome copy number variation analysis to detect genomic regions for resistance to Haemonchus contortus in Sheep.BMC genomics · 2026Article
- RNA sequencing analysis in chicken spleen infected with Newcastle disease virus reveals genotype-specific immune response.BMC genomics · 2025Article
- Influence of genetics and the pre-vaccination blood transcriptome on the variability of antibody levels after vaccination against Mycoplasma hyopneumoniae in pigs.Genetics, selection, evolution : GSE · 2021Article
- Genome-Wide Association Study of Growth Performance and Immune Response to Newcastle Disease Virus of Indigenous Chicken in Rwanda.Frontiers in genetics · 2021Article
- Heritability Estimate for Antibody Response to Vaccination and Survival to a Newcastle Disease Infection of Native chicken in a Low-Input Production System.Frontiers in genetics · 2021Article
- Integrated Transcriptome and Histone Modification Analysis Reveals NDV Infection Under Heat Stress Affects Bursa Development and Proliferation in Susceptible Chicken Line.Frontiers in genetics · 2020Article
- Genetic Basis of Response of Ghanaian Local Chickens to Infection With a Lentogenic Newcastle Disease Virus.Frontiers in genetics · 2020Article
- Genetic Analyses of Tanzanian Local Chicken Ecotypes Challenged with Newcastle Disease Virus.Genes · 2019Article
- Article
- SNPrune: an efficient algorithm to prune large SNP array and sequence datasets based on high linkage disequilibrium.Genetics, selection, evolution : GSE · 2018Article
- Annotating long intergenic non-coding RNAs under artificial selection during chicken domestication.BMC evolutionary biology · 2017Article
- Genome-wide association study for performance traits in chickens using genotype by sequencing approach.Scientific reports · 2017Article
- Genome-wide association study dissects genetic architecture underlying longitudinal egg weights in chickens.BMC genomics · 2015Article
- Stories and Challenges of Genome Wide Association Studies in Livestock - A Review.Asian-Australasian journal of animal sciences · 2015Article
- Genome-wide association study of antibody level response to NDV and IBV in Jinghai yellow chicken based on SLAF-seq technology.Journal of applied genetics · 2015Article
- A genome-wide association study in catfish reveals the presence of functional hubs of related genes within QTLs for columnaris disease resistance.BMC genomics · 2015Article
- The identification of loci for immune traits in chickens using a genome-wide association study.PloS one · 2015Article
- A genome-wide association study identifies major loci affecting the immune response against infectious bronchitis virus in chicken.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2014Article
- Genomic selection for the improvement of antibody response to Newcastle disease and avian influenza virus in chickens.PloS one · 2014Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSince the first outbreak in Indonesia in 1926, Newcastle disease has become one of the most common and contagious bird diseases throughout the world. To date, enhancing host antibody response by vaccination remains the most efficient strategy to control outbreaks of Newcastle disease. Antibody response plays an important role in host resistance to Newcastle disease, and selection for antibody response can effectively improve disease resistance in chickens. However, the molecular basis of the variation in antibody response to Newcastle disease virus (NDV) is not clear. The aim of this study was to detect genes modulating antibody response to NDV by a genome-wide association study (GWAS) in chickens.
resultsTo identify genes or chromosomal regions associated with antibody response to NDV after immunization, a GWAS was performed using 39,833 SNP markers in a chicken F(2) resource population derived from a cross between two broiler lines that differed in their resistance. Two SNP effects reached 5% Bonferroni genome-wide significance (P<1.26×10(-6)). These two SNPs, rs15354805 and rs15355555, were both on chicken (Gallus gallus) chromosome 1 and spanned approximately 600 Kb, from 100.4 Mb to 101.0 Mb. Rs15354805 is in intron 7 of the chicken Roundabout, axon guidance receptor, homolog 2 (ROBO2) gene, and rs15355555 is located about 243 Kb upstream of ROBO2. Rs15354805 explained 5% of the phenotypic variation in antibody response to NDV, post immunization, in chickens. Rs15355555 had a similar effect as rs15354805 because of its linkage disequilibrium with rs15354805 (r(2)=0.98).
conclusionThe region at about 100 Mb from the proximal end of chicken chromosome 1, including the ROBO1 and ROBO2 genes, has a strong effect on the antibody response to the NDV in chickens. This study paves the way for further research on the host immune response to NDV.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.