ArticleBMC cancer2013
Genetic association between selected cytokine genes and glioblastoma in the Han Chinese population.
Article in BMC cancer, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- Association of the interleukin-4Rα rs1801275 and rs1805015 polymorphisms with glioma risk.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Pooled it
- Single-Nucleotide Polymorphisms Related to Glioblastoma Risk and Worldwide Epidemiology: A Systematic Review and Meta-Analysis.Journal of personalized medicine · 2025Review
- Association between IL1B gene and cervical cancer susceptibility in Chinese Uygur Population: A Case-Control study.Molecular genetics & genomic medicine · 2019Article
- Genetic Association between Interleukin-4 Receptor Polymorphisms and Cancer Susceptibility: A Meta-Analysis Based on 53 Case-Control Studies.Journal of Cancer · 2019Article
- Association of three promoter polymorphisms in interleukin-10 gene with cancer susceptibility in the Chinese population: a meta-analysis.Oncotarget · 2017Article
- Article
- Polymorphism of theBalkan journal of medical genetics : BJMG · 2016Article
- Polymorphism in the IL4R gene and clinical features are associated with glioma prognosis: Analyses of case-cohort studies.Medicine · 2016Observational
- Association between interleukin-4 gene intron 3 VNTR polymorphism and cancer risk.Cancer cell international · 2014Article
- Impact of single nucleotide polymorphism in IL-4, IL-4R genes and systemic concentration of IL-4 on the incidence of glioma in Iraqi patients.International journal of medical sciences · 2014Article
- Association of Interleukin-4 Polymorphisms With Breast Cancer in Taiwan.In vivo (Athens, Greece)Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGlioblastoma (GBM) is the most malignant brain tumor. Many abnormal secretion and expression of cytokines have been found in GBM, initially speculated that the occurrence of GBM may be involved in these abnormal secretion of cytokines. This study aims to detect the association of cytokine genes with GBM.
methodsWe selected seven tag single nucleotide polymorphisms (tSNPs) in six cytokine genes, which previously reported to be associated with brain tumors, and analyzed their association with GBM in a Han Chinese population using χ(2) test and genetic model analysis.
resultsWe found two risk tSNPs and one protective tSNP. By χ(2) test, the rs1801275 in IL-4R showed an increased risk of GBM. In the genetic model analysis, the genotype "TC" of rs20541 in IL-13 gene showed an increased risk of GBM in over-dominant model (OR = 2.00; 95% CI, 1.13-3.54, p = 0.015); the genotype "CT" of rs1800871 in the IL-10 gene showed a decrease risk in the over-dominant model (OR = 0.57; 95% CI, 0.33 - 0.97; p = 0.037). The genotype "AG" of rs1801275 in the IL-4R gene showed an increase risk in over-dominant model (OR = 2.29; 95% CI, 1.20 - 4.35; p = 0.0081) We further analyzed whether the six cytokine genes have a different effect on the disease in gender specific population, and found that the allele "G" of rs2243248 in the IL-4 gene showed a decrease risk of GBM in female (OR = 0.35, 95% CI, 0.13 - 0.94, p = 0.0032), but the allele "T" showed a decrease risk in male (OR = 0.30, 95% CI, 0.17 - 0.53, p = 0.0032).
conclusionsOur findings, combined with previously reported results, suggest that cytokine genes have potential role in GBM development, which may be useful to early prognostics for GBM in the Han Chinese population.
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