ArticleThe World Allergy Organization journal2013
The biodiversity hypothesis and allergic disease: world allergy organization position statement.
Article in The World Allergy Organization journal, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 146 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
146 citing papers in PubMed, 1 synthesis or guideline pooled it, 409 citations in OpenAlex.
- Pooled it
- Respiratory morbidity at age 4 across COVID-19 and pre-pandemic birth cohorts: the role of atopic risk.European journal of pediatrics · 2026Article
- Climate classification, sociodemographic development, and the burden of inflammatory bowel disease in tropical countries.Tropical medicine and health · 2026Article
- Beyond Infection-Indoor Airborne Pathogens as Contributors to Respiratory Inflammation and Immune Dysregulation: A Narrative Review.Pathogens (Basel, Switzerland) · 2026Review
- [Gut microbiota and allergic diseases].Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2026Review
- Microbial diversity as the next frontier of payments for ecosystem services in nature-positive finance.npj biodiversity · 2026Review
- Rethinking Microbiome of the Built Environment (MoBE) Management: From Pathogen-Centric Control to Microbiome-Informed Engineering.Environmental science & technology · 2026Article
- Overview of allergic disease: Pathogenesis of allergic inflammation - WAO White Book on Allergy 2026 - 2.1.The World Allergy Organization journal · 2026Review
- Homo sapiens, industrialisation and the environmental mismatch hypothesis.Biological reviews of the Cambridge Philosophical Society · 2026Review
- Residential greenness and atopic dermatitis in Japanese children: Findings from the TMM BirThree cohort study.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2026Article
- Nature prescription for patients with chronic respiratory diseases.The World Allergy Organization journal · 2026Review
- Review
- The interconnection between environment, immune-nutrition and allergic disease.Asia Pacific allergy · 2026Article
- Dietary fructo-oligosaccharides dose-dependently modulate the microbiome and suppress type 2 lung inflammation in a murine model of house dust mite-induced allergic asthma.Frontiers in nutrition · 2026Article
- Sustainable rewilding of urban spaces increases microbial diversity.Sustainable microbiology · 2026Article
- The nasal-oral microbiome axis in allergic rhinitis: environmental triggers, microbial dysbiosis, and immune dysregulation.Frontiers in allergy · 2026Review
- Beyond breastfeeding: a One Health Decalogue for nurturing the infant microbiota.Frontiers in nutrition · 2026Review
- The sterile society: hyperselection and the loss of adaptive variance.Frontiers in psychology · 2026Article
- Impacts of COVID-19 pandemic on early life gut microbiome.Gut microbes · 2025Article
- Shotgun metagenomics reveals distinct skin microbial species in allergen-sensitized individuals.Microbial genomics · 2025Article
86 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 8 institutions in 7 countries.
Funding
Abstract
Biodiversity loss and climate change secondary to human activities are now being associated with various adverse health effects. However, less attention is being paid to the effects of biodiversity loss on environmental and commensal (indigenous) microbiotas. Metagenomic and other studies of healthy and diseased individuals reveal that reduced biodiversity and alterations in the composition of the gut and skin microbiota are associated with various inflammatory conditions, including asthma, allergic and inflammatory bowel diseases (IBD), type1 diabetes, and obesity. Altered indigenous microbiota and the general microbial deprivation characterizing the lifestyle of urban people in affluent countries appear to be risk factors for immune dysregulation and impaired tolerance. The risk is further enhanced by physical inactivity and a western diet poor in fresh fruit and vegetables, which may act in synergy with dysbiosis of the gut flora. Studies of immigrants moving from non-affluent to affluent regions indicate that tolerance mechanisms can rapidly become impaired in microbe-poor environments. The data on microbial deprivation and immune dysfunction as they relate to biodiversity loss are evaluated in this Statement of World Allergy Organization (WAO). We propose that biodiversity, the variability among living organisms from all sources are closely related, at both the macro- and micro-levels. Loss of the macrodiversity is associated with shrinking of the microdiversity, which is associated with alterations of the indigenous microbiota. Data on behavioural means to induce tolerance are outlined and a proposal made for a Global Allergy Plan to prevent and reduce the global allergy burden for affected individuals and the societies in which they live.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.