ArticlePsychological medicine2014
Transdiagnostic and disorder-specific models of intergenerational transmission of internalizing pathology.
Article in Psychological medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 28 papers, 1 of them a synthesis that pooled it.
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 54 citations in OpenAlex.
- Prevention programmes for children of parents with a mood/anxiety disorder: Systematic review of existing programmes and meta-analysis of their efficacy.The British journal of clinical psychology · 2021Pooled it
- Intergenerational transmission of anxiety: A comparison of transdiagnostic and disorder-specific pathways.JCPP advances · 2026Article
- A prospective investigation of whether parent psychopathology explains the relationship between parent maltreatment and offspring mental health.Development and psychopathology · 2026Article
- Internalizing problems can differ in boys and girls since early childhood: findings from the Child Behavioral Checklist 1.5-5.Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999) · 2025Article
- Fluctuations in Maternal Depressive Symptoms, Anxiety, and Anger and Children's Depression Risks in Middle Childhood.Research on child and adolescent psychopathology · 2024Article
- Internalizing psychopathology and its links to suicidal ideation, dysfunctional attitudes, and help-seeking readiness in a national sample of college students.Journal of affective disorders · 2024Article
- Mothers with Dysregulated Eating and Their Offspring's Emotional/Behavioral Functioning during the COVID-19 Pandemic: A Descriptive Study.Journal of clinical medicine · 2024Article
- Intergenerational Transmission of Psychiatric Conditions and Psychiatric, Behavioral, and Psychosocial Outcomes in Offspring.JAMA network open · 2023Article
- Integrating Treatment for Maternal Depression and Young Children's Behavior Problems.Journal of psychiatry and brain science · 2023Article
- Maternal symptoms of depression and anxiety during the postpartum period moderate infants' neural response to emotional faces of their mother and of female strangers.Cognitive, affective & behavioral neuroscience · 2022Article
- Transdiagnostic development of internalizing psychopathology throughout the life course up to age 45: a World Mental Health Surveys report.Psychological medicine · 2022Article
- Intergenerational transmission of depressive and anxiety disorders: Mediation via youth personality.Journal of psychopathology and clinical science · 2022Article
- Neurobiological, familial and genetic risk factors for dimensional psychopathology in the Adolescent Brain Cognitive Development study.Molecular psychiatry · 2022Article
- Racial discrimination and other adverse childhood experiences as risk factors for internalizing mental health concerns among Black youth.Journal of traumatic stress · 2022Article
- The Impact of Personality Pathology Across Three Generations: Evidence from the St. Louis Personality and Intergenerational Network Study.Clinical psychological science : a journal of the Association for Psychological Science · 2021Article
- Multiple domains of risk factors for first onset of depression in adolescent girls.Journal of affective disorders · 2021Article
- Intergenerational transmission of maternal overprotection and child anxiety in substance-using families.Journal of anxiety disorders · 2020Article
- Redefining phenotypes to advance psychiatric genetics: Implications from hierarchical taxonomy of psychopathology.Journal of abnormal psychology · 2020Review
- A choose your own adventure story: Conceptualizing depression in children and adolescents from traditional DSM and alternative latent dimensional approaches.Behaviour research and therapy · 2019Review
- Transdiagnostic psychiatry: a systematic review.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2019Article
Corrections and comments
- Erratum issued
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundNumerous studies have supported an association between maternal depression and child psychiatric outcomes, but few have controlled for the confounding effects of both maternal and offspring co-morbidity. Thus, it remains unclear whether the correspondence between maternal and offspring depressive and anxiety disorders is better explained by associations between shared features of maternal and offspring internalizing disorders or by specific effects exerted by unique aspects of individual disorders.
methodPairs of mothers and offspring overselected for maternal depression (n = 815) were assessed at offspring age 15 years for anxiety and depressive disorders; 705 completed a follow-up at offspring age 20 years. For both mothers and offspring, structural equation modeling was used to distinguish transdiagnostic internalizing pathology--representing the overlap among all depressive and anxiety disorders--from diagnosis-specific forms of pathology. To discriminate between general versus specific pathways of intergenerational transmission of psychopathology, we examined (a) the general association between the maternal and offspring internalizing factors and (b) the correlations between maternal and offspring diagnosis-specific pathology for each disorder.
resultsFor mothers and offspring, a unidimensional latent variable model provided the best fit to the correlations among depressive and anxiety disorders. The maternal transdiagnostic internalizing factor strongly predicted the corresponding factor among offspring. In addition, the unique component of post-traumatic stress disorder among offspring was significantly related to the analogous unique component among mothers, but specific components of other maternal disorders, including depression, did not predict corresponding offspring pathology.
conclusionsResults suggest that intergenerational transmission of internalizing disorders is largely non-specific.
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