Evidence map›Paper›PMID 23662819›Full record

ArticleJournal of neurosurgery2013

Complement polymorphisms and cognitive dysfunction after carotid endarterectomy.

Eric J Heyer, Christopher P Kellner, Hani R Malone, Samuel S Bruce, Joanna L Mergeche, Justin T Ward, E Sander Connolly

Expression of concern Registry-linked trialAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neurosurgery, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It carries an expression of concern. It is linked to trial NCT00597883 (Neurologic and Neuropsychometric Outcome in Patients Undergoing Carotid Endarterectomy), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00597883 completednot on this map

Neurologic and Neuropsychometric Outcome in Patients Undergoing Carotid Endarterectomy

TypeobservationalSponsorColumbia UniversityRan2003 to 2014Enrolled817ConditionsCarotid Artery Stenosis, Carotid Artery Disease, Transient Ischemic Attack, StrokeArmsCarotid endarterectomy, Neurological and neuropsychological evaluations
3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Observational
  2. Review
  3. Article
  4. Observational
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Eric J HeyerDepartment of Anesthesiology, Columbia University, New York, New York, USA. ejh3@columbia.edu
Christopher P Kellner
Hani R Malone
Samuel S Bruce
Joanna L Mergeche
Justin T Ward
E Sander Connolly

Funding

CTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCHUL1RR024156 · NCRR · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GINSBERG, HENRY N · 2006 to 2011
$53.0M
Clinical and Translational Science AwardUL1TR000040 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GINSBERG, HENRY N · 2012 to 2015
$26.2M
Neuropsychological Outcome of Carotid EndarterectomyR01AG017604 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI HEYER, ERIC JOHN · 2001 to 2012
$3.2M
NCATS NIH HHS UL1 TR000040NCRR NIH HHS UL1 RR024156NIA NIH HHS R01 AG017604NIA NIH HHS R01 AG17604-9
6 · The paper itself

Abstract

objectThe role of genetic polymorphisms in the neurological outcome of patients after carotid endarterectomy (CEA) remains unclear. There are single nucleotide polymorphisms (SNPs) that predispose patients to postoperative cognitive dysfunction (CD). We aim to assess the predictability of three complement cascade-related SNPs for CD in patients having CEAs.

methodsIn 252 patients undergoing CEA, genotyping was performed for the following polymorphisms: complement component 5 (C5) rs17611, mannose-binding lectin 2 (MBL2) rs7096206, and complement factor H (CFH) rs1061170. Differences among genotypes were analyzed via the chi-square test. Patients were evaluated with a neuropsychometric battery for CD 1 day and 1 month after CEA. A multiple logistic regression model was created. All variables with univariate p < 0.20 were included in the final model.

resultsThe C5 genotypes A/G (OR 0.26, 95% CI 0.11-0.60, p = 0.002) and G/G (OR 0.22, 95% CI 0.09-0.52, p < 0.001) were significantly associated with lower odds of exhibiting CD at 1 day after CEA compared with A/A. The CFH genotypes C/T (OR 3.37, 95% CI 1.69-6.92, p < 0.001) and C/C (OR 3.67, 95% CI 1.30-10.06, p = 0.012) were significantly associated with higher odds of exhibiting CD at 1 day after CEA compared with T/T. Statin use was also significantly associated with lower odds of exhibiting CD at 1 day after CEA (OR 0.43, 95% CI 0.22-0.84, p = 0.01). No SNPs were significantly associated with CD at 1 month after CEA.

conclusionsThe presence of a deleterious allele in the C5 and CFH SNPs may predispose patients to exhibit CD after CEA. This finding supports previous data demonstrating that the complement cascade system may play an important role in the development of CD. These findings warrant further investigation.

Indexed as

AgedAged, 80 and overCognition DisordersCohort StudiesComplement C5Complement Factor HEndarterectomy, CarotidFemaleHumansMaleMannose-Binding LectinMiddle AgedPolymorphism, Single NucleotidePostoperative ComplicationsPromoter Regions, GeneticProspective StudiesComplement C5Complement Factor HMannose-Binding LectinMBL2 protein, human

Identifiers

PMID23662819
PMCPMC3806214

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.