ReviewActa psychiatrica Scandinavica2013
The neurobiological correlates of childhood adversity and implications for treatment.
Review in Acta psychiatrica Scandinavica, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
53 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The Impact of the COVID-19 Pandemic on Mental Health and Cognitive Function in Patients With Cancer: A Systematic Literature Review.Cancer reports (Hoboken, N.J.) · 2024Pooled it
- A naturalistic, multi-site study of repetitive transcranial magnetic stimulation therapy for depression.Journal of affective disorders · 2017Trial
- A history of early life parental loss or separation is associated with successful cognitive-behavioral therapy in major depressive disorder.Journal of affective disorders · 2015Trial
- Positive affect as a developmental mediator of early adversity and internalizing psychopathology.Journal of child psychology and psychiatry, and allied disciplines · 2026Article
- Article
- Early life stress enhances the association between residential nature exposure and fasting blood glucose.PloS one · 2026Article
- Attention to facial emotions in adult women varies by type and severity of childhood maltreatment experience and emotion regulation strategy.Scientific reports · 2025Article
- Associations between childhood maltreatment and personality traits in individuals with and without depression: a CTQ-based assessment.BMC psychology · 2025Article
- Cluster analysis exploring the impact of childhood neglect on cognitive function in patients with bipolar disorder.International journal of bipolar disorders · 2024Article
- No evidence of accelerated epigenetic aging among black heroin users: A case vs control analysis.Addiction neuroscience · 2023Article
- Fight the Fire: Association of Cytokine Genomic Markers and Suicidal Behavior May Pave the Way for Future Therapies.Journal of personalized medicine · 2023Review
- Child Maltreatment and Long-Term Physical and Mental Health Outcomes: An Exploration of Biopsychosocial Determinants and Implications for Prevention.Child psychiatry and human development · 2023Review
- Do childhood adversity and sensory processing sensitivity interact to predict meaningful activity engagement in adulthood?The British journal of occupational therapy · 2023Article
- Building resilience through daily smartphone app use: results of a pilot study of the JoyPop app with social work students.Frontiers in digital health · 2023Article
- Childhood trauma and psychological sub-health among Chinese adolescents: the mediating effect of Internet addiction.BMC psychiatry · 2022Article
- Experiences of maltreatment in childhood and attention to facial emotions in healthy young women.Scientific reports · 2022Article
- Childhood trauma determines different clinical and biological manifestations in patients with eating disorders.Eating and weight disorders : EWD · 2021Observational
- Early Life Adversity as a Moderator of Symptom Change following Selective Serotonin Reuptake Inhibitors and Cognitive Behavioral Therapy.Cognitive therapy and research · 2021Article
- Adverse Childhood Experiences and Building Resilience With the JoyPop App: Evaluation Study.JMIR mHealth and uHealth · 2021Article
- How to Support Parents of Infants and Young Children in Mental Health Care: A Narrative Review.Frontiers in psychology · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
objectiveThis article provides an overview of research on the neurobiological correlates of childhood adversity and a selective review of treatment implications.
methodFindings from a broad array of human and animal studies of early adversity were reviewed.
resultsTopics reviewed include neuroendocrine, neurotrophic, neuroimaging, and cognitive effects of adversity, as well as genetic and epigenetic influences. Effects of early-life stress on treatment outcome are considered, and development of treatments designed to address the neurobiological abnormalities is discussed.
conclusionEarly adversity is associated with abnormalities of several neurobiological systems that are implicated in the development of psychopathology and other medical conditions. Early-life stress negatively impacts treatment outcome, and individuals may require treatments that are specific to this condition.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.