ArticleJournal of biochemical and pharmacological research2013
Protein Oxidative Modifications: Beneficial Roles in Disease and Health.
Article in Journal of biochemical and pharmacological research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 126 papers.
What it found
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Who cites it
126 citing papers in PubMed, 209 citations in OpenAlex.
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- Oxidative stress and fetal weight: observational findings from a pregnancy cohort in New York City.Journal of perinatology : official journal of the California Perinatal Association · 2026Observational
- Reactive Oxygen Species-Induced Modifications of Fibrin Clots as a Link Between Immune Responses and Atherothrombosis in Systemic Lupus Erythematosus.Arthritis & rheumatology (Hoboken, N.J.) · 2026Article
- Attenuation of chlorpyrifos-induced liver injury, oxidative stress and inflammation by selenium nanoparticles via SIRT1/FXR/Nrf2 signaling pathway modulation.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Protective effects of taxifolin against gentamicin-induced nephrotoxicity in mice: modulation of oxidative stress, inflammation, apoptosis, and Nrf2 signaling.Naunyn-Schmiedeberg's archives of pharmacology · 2025Article
- Selenium nanoparticles mitigate chlorpyrifos-induced nephrotoxicity by modulating oxidative stress, inflammation, and the SIRT1/Nrf2/HO-1 signaling pathway.Journal of molecular histology · 2025Article
- Early-Stage Alcoholic Cardiomyopathy Highlighted by Metabolic Remodeling, Oxidative Stress, and Cardiac Myosin Dysfunction in Male Rats.International journal of molecular sciences · 2025Article
- Analysis of the SARS-CoV-2 inactivation mechanism using violet-blue light (405 nm).Applied and environmental microbiology · 2025Article
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- Major Oxidative and Antioxidant Mechanisms During Heat Stress-Induced Oxidative Stress in Chickens.Antioxidants (Basel, Switzerland) · 2025Review
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- Proteomics- and metabolomics-based analysis of the regulation of germination in Norway maple and sycamore embryonic axes.Tree physiology · 2025Article
- The ameliorative potential of metformin against aluminum-induced neurotoxicity: Insights from in vitro studies.Journal of applied toxicology : JAT · 2025Article
- Modulation of pulmonary immune functions by theFrontiers in immunology · 2025Review
- MosGraphFlow: a novel integrative graph AI model mining signaling targets from multi-omic data.BMC methods · 2025Article
- The role of oxidative post-translational modifications in type 1 diabetes pathogenesis.Frontiers in immunology · 2025Review
66 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Protein oxidative modifications, also known as protein oxidation, are a major class of protein posttranslational modifications. They are caused by reactions between protein amino acid residues and reactive oxygen species (ROS) or reactive nitrogen species (RNS) and can be classified into two categories: irreversible modifications and reversible modifications. Protein oxidation has been often associated with functional decline of the target proteins, which are thought to contribute to normal aging and age-related pathogenesis. However, it has now been recognized that protein oxidative modifications can also play beneficial roles in disease and health. This review summarizes and highlights certain positive roles of protein oxidative modifications that have been documented in the literature. Covered oxidatively modified protein adducts include carbonylation, 3-nitrotyrosine, s-sulfenation, s-nitrosylation, s-glutathionylation, and disulfide formation. All of which have been widely analyzed in numerous experimental systems associated with redox stress conditions. The authors believe that selected protein targets, when modified in a reversible manner in prophylactic approaches such as preconditioning or ischemic tolerance, may provide potential promise in maintaining health and fighting disease.
Indexed as
Identifiers
23662248PMC3646577W2142025319What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.